The Indian Journal of Pediatrics

, Volume 59, Issue 6, pp 749–754 | Cite as

Risk factors for recurrence of febrile convulsions

  • N. Thilothammal
  • V. Shalini Devi
  • K. G. Kamala
  • K. Banu
  • S. R. Ratnam
  • S. Ezhilarasi
Original Articles


A cohort of hundred children with febrile convulsions, in the age group of 3 months to 5 years were followed up prospectively for one year to study the natural course of the illiness, and to determine if specific factors would increase the risk of recurrence of febrile convulsions.

The risk factors studied were age of onset under one year, long duration of convulsion (more than 15 minutes), family history of febrile convulsion or epilepsy and combination of two or all of the above factors. Four groups of children with different risk factors were followed up for recurrence of convulsion, after the first attack. A group of children without any risk factor was considered as control and they were also followed up for recurrence of convulsions.

Though all the groups with the risk factors, showed a trend towards a higher recurrence rate when compared to controls, the difference observed clinically was not significant statistically. This could be due to the small sample size of each group. A larger study could throw light on the predictive value of these risk factors and narrow down the use of long term anticonvulsant prophylaxis.

Key words

Febrile convulsions Risk factors Cohort study 


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  1. 1.
    Ouellette EM. The child who convulses with fever.Pediatr Clin North Am 1974; 21: 467–481.PubMedGoogle Scholar
  2. 2.
    Richard E. Behrman, Victor C. Vaughan and Nelson WE.Nelson's Text book of Paediatrics. XIII Edition's. Philadelphia: WB Saunders Company 1987; 1287–1292.Google Scholar
  3. 3.
    Hirtz DG. Generalised tonic-clonic and febrile seizures.Pediatr Clin North Am 1989; 36: 375–382.Google Scholar
  4. 4.
    Rutter N. Febrile convulsions—What do parents do?Br Med J 1978; 2: 1345.PubMedGoogle Scholar
  5. 5.
    Nelson KB, Ellenberg JH. Predictors of epilepsy in children who have experienced febrile seizures.N Engl J Med 1976; 295: 1029–1033.PubMedCrossRefGoogle Scholar
  6. 6.
    Livingston S. Febrile convulsions. In: Thomas CC, ed.Comprehensive Management of Epilepsy in Infancy, Childhood and Adolescence, Illinois: Springfield, 1972: 16–33.Google Scholar
  7. 7.
    Millichap JG.Febrile Convulsions. New York: MacMillan, 1968.Google Scholar
  8. 8.
    Knudsen F. Recurrence risk after first febrile seizure and effect of short term diazepam prophylaxis.Arch Dis Child 1985; 60: 1045–1049.PubMedCrossRefGoogle Scholar
  9. 9.
    Consensus statement. Febrile seizures. A consensus of their significance, evaluation and treatment.Pediatrics 1980; 66: 1009–1012.Google Scholar
  10. 10.
    John Annegers et al. Factors prognostic of unprovoked seizures after febrile convulsion.N Engl J Med 1987; 316: 493–498.PubMedCrossRefGoogle Scholar
  11. 11.
    Wallace SJ, Smith JA. Recurrence of convulsions in febrile children on no anticonvulsants. In: Dam M, Gram L and Penry JK, eds.Advances in Epileptology: XIIth Epilepsy International Symposium. New York: Raven Press, 1981.Google Scholar
  12. 12.
    Ellenberg JH, Nelson KB. Febrile seizures and later intellectual performance.Arch Neurol 1978; 35: 17–21.PubMedGoogle Scholar
  13. 13.
    Nelson KB, Ellenberg JH. Prognosis in children with febrile seizures.Pediatrics 1978; 61: 720–727.PubMedGoogle Scholar
  14. 14.
    Ramakrishnan K, Thomas K. Long term prophylaxis of febrile seizures.Indian J Pediatr 1986; 53: 397–400.PubMedCrossRefGoogle Scholar
  15. 15.
    Sheldon SW et al. Value of phenobarbitone in the child who had a single febrile convulsion: A controlled prospective study.Pediatrics 1977; 5: 378–385.Google Scholar
  16. 16.
    Livingston S, Berman W, Pauli L. Febrile convulsions.Lancet 1973; 2: 1441–1443.PubMedCrossRefGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 1992

Authors and Affiliations

  • N. Thilothammal
    • 1
  • V. Shalini Devi
    • 1
  • K. G. Kamala
    • 1
  • K. Banu
    • 1
  • S. R. Ratnam
    • 1
  • S. Ezhilarasi
    • 1
  1. 1.Clinical Epidemiology UnitInstitute of Child Health & Hospital for ChildrenMadras

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