Advertisement

Free—draining intraperitoneal pancreatic segmental autografting in canine

  • Chen Shi
  • Zhu Wenhui
  • Ma Xuxian
  • Xia Suisheng
Article

Summary

In this study we attempt to define the result of pancreas transplantation with the duct left open to drain freely into the peritoneal cavity. Twenty dogs underwent total pancreatectomy, splenectomy, and segmental pancreas transplantation with this technique. Eighteen of the twenty animals recovered normal blood sugar and serum insulin levels 24 hrs after operation. Up to date, the longest survival time is 5 months with excellent pancreatic function. Pancreatic biopsies obtained from animals 45 days after transplantation showed that the islet cells were normal, the acinar tissue was normal on the whole and interlobular connective tissue showed slight proliferation.

In this report we advocate creation of an arteriovenous fistula between the splenic artery and vein at the tail of the graft in order to markedly reduce the incidences of thrombosis in the graft vessels and hemorrhagic pancreatitis.

Our study concludes that segmental pancreas transplantation with unligated duct is a better approach to transplantation of pancreas. This technique is recommended for clinical application.

Key words

free-draining intraperitoneal segmental pancreas transplantation splenic arteriovenous fistula 

Freidrainierende intraperitoneale segmentale Pankreasautotransplantation beim Hund

References

  1. 1.
    Dickerman RM, et al: Transplantation of the pancreas into a retroperitoneal jejunal loop. Am J Surg 129:48, 1975PubMedCrossRefGoogle Scholar
  2. 2.
    Gliedman ML, et al Pancreatic duct to ureter anastomosis for exocrine drainage in pancreatic transplantation. Am J Surg 125,:245, 1973PubMedCrossRefGoogle Scholar
  3. 3.
    Dubernard JM, et al: A new method of preparation of segmental pancreatic graft for transplantation: Trials in dogs and in man. Surgery 84:633, 1978PubMedGoogle Scholar
  4. 4.
    Groth CG, et al: Rejection of isolated pancreatic allografts in patients with diabetes. SGO 143:933, 1976PubMedGoogle Scholar
  5. 5.
    Gliedman ML, et al: Clinical segmental pancreatic transplantation with ureterpancreatic duct anastomosis for exocrine drainage. Surgery 74:171, 1973PubMedGoogle Scholar
  6. 6.
    Kyriakides GK, et al: Segmental pancreatic transplantation in dogs. Transplant Proc 11:530, 1979PubMedGoogle Scholar
  7. 7.
    Kyriakides GK, et al: Segmental pancreatic transplantation in pigs. Surgery 85:154, 1979PubMedGoogle Scholar
  8. 8.
    Baumgartner D, et al: Long-term canine segmental pancreas transplants with the duct left open, Neoprene-injected duct, and pancreaticoureterostomy: A comparative study. Transplant Proc 13:812, 1981PubMedGoogle Scholar
  9. 9.
    Sutherland, DER, et al: Intraperitoneal transplantation of immediately vascularized segmental pancreatic grafts without duct ligation. Transplantation 28:485, 1979PubMedCrossRefGoogle Scholar
  10. 10.
    Sutherland DER, et al: Report of twelve clinical cases of segmental pancreas transplantation at the University of Minnesota. Transplant Proc 12 (Suppl 2):33, 1980PubMedGoogle Scholar

Copyright information

© Wuhan Medical College 1982

Authors and Affiliations

  • Chen Shi
    • 1
  • Zhu Wenhui
    • 1
  • Ma Xuxian
    • 1
  • Xia Suisheng
    • 1
  1. 1.Department of Experimental Research, Institute of Organ TransplantationWuhan Medical CollegeWuhan

Personalised recommendations