Reactions with hydrazidoyl halides (V)1): synthesis of some amidrazones, hydrazides, pyrazoles and pyrazolo[3,4-d]pyridazine derivatives

  • Fawzy A. Attaby
  • Mayssoune Y. Zaki
  • Abdou O. Abdelhamid
  • Nazmy A. Ramadan
Original Articles


2-Bromo (2′-benzofuryl)glyoxal-2-arylhydrazonesI reacted with nucleophiles displacing the bromide. Treatment ofI with active methylene compounds yield the pyrazole derivativesVIII–XI. CompoundsXII–XIV reacted with hydrazine to give pyrazolo[3,4-d]pyridazine derivativeXIV–XVI. The structures of the products were assigned and confirmed on the basis of their elemental analysis and spectral data.


Amidrazones hydrazidoyl halides hydrazides pyrazoles pyrazolopyridazines 

Literature Cited

  1. 1.
    Part IV. Abdelhamid, A.O. and Attaby, F.A.:J. Heterocyclic Chem. in press (1990).Google Scholar
  2. 2.
    Huisgen, R., Grashey, R. and Sauer, J.: InThe Chemistry of Alkenes, S. Patai, ed., Interscience. p.812, (1964).Google Scholar
  3. 3.
    Bianchi, G., DeMicheli, C. and Gandolfi, R.: InThe Chemistry of Double Bonded Functional Groups, Part I, S. Patai, ed., John Wiley and Sons, New York, p. 421, (1977).Google Scholar
  4. 4.
    Pocar, D., Rossi, L.M. and Trimarco, P.:J. Heterocyclic Chem. 12, 401 (1975).Google Scholar
  5. 5.
    Abdelhamid, A.O., Parkanyi, C., Shawali, A.S. and Abdalla, M.A.:J. Heterocyclic Chem. 21, 1049 (1984).Google Scholar
  6. 6.
    Parkanyi, C., Abdelhamid, A.O. and Shawali, A.S.:J. Heterocyclic Chem. 21, 521 (1984).CrossRefGoogle Scholar
  7. 7.
    Abdelhamid, A.O., Abbas, Ikhlass, M., Abdalla, M.A., Fahmi, A.A. and Shawali, A.S.:J. Heterocyclic Chem. 22, 813 (1983).Google Scholar
  8. 8.
    Abdelhamid, A.O., Hassaneen, H.M. and Shawali, A.S.:J. Heterocyclic Chem. 22, 543 (1985).Google Scholar
  9. 9.
    Abdelhamid, A.O. and Afifi, M.A.:Phosphorous and sulfur,38, 129 (1988).CrossRefGoogle Scholar
  10. 10.
    Abdelhamid, A.O. and Shawali, A.S.:Z. Naturforsch. 42b, 613 (1986).Google Scholar
  11. 11.
    Shawali, A.S., Abdelhamid, A.O. and Hassaneen, H.M.:Indian J. Chem.,10, 965 (1972).Google Scholar
  12. 12.
    Abdelhamid, A.O., Attaby, F.A. and Zaki, M.Y.:Phosphrous and Sulfur, in press (1989).Google Scholar

Copyright information

© The Pharmaceutical Society of Korea 1990

Authors and Affiliations

  • Fawzy A. Attaby
    • 1
  • Mayssoune Y. Zaki
    • 1
  • Abdou O. Abdelhamid
    • 1
  • Nazmy A. Ramadan
    • 2
  1. 1.Department of Chemistry, Faculty of ScienceCairo UniversityGiza
  2. 2.Petroleum Research InstituteCairoEgypt

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