Archives of Pharmacal Research

, Volume 13, Issue 1, pp 108–112 | Cite as

Biochemical studies on hypoglycemic agents (I) effect ofAzadirachta indica leaf extract

  • Z. M. El-Hawary
  • T. S. Kholief


It was confirmed that extracts of some plants were used in folklore medicine as hypoglycemic agents. Of these plants isAzadirachta indica (“neem”), which grows in tropical regions. The present study deals with biochemical effects of the “neem” leaf water extract given orally to experimental animals, especially the hypoglycemic characteristics. Normals as well as alloxan diabetic rats have been used in this work. The results showed that the “neem” leaf extract produced some hypoglycemia in normal rats when given in two doses, while in diabetic rats there was a decrease in blood sugar, but it could not alleviate the diabetic state. However, the “neem” leaf extract produced some toxic effects in rats, as observed that the clotting time of blood was higher than that of the normal. Serum cholesterol level increased with concomitant decrease in the liver fat as compared to normal levels. There was also a drop in liver proteins which was dose-related. The results were compared with those obtained with an oral hypoglycemic drug (Glibenclamide).


Diabetes hypoglycemia Azadirachta indica 


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Literature Cited

  1. 1.
    Thompson, B.E. and Anderson, C.C.: EffectsAzadirachta indica on cardiovascular system,J. Pharmacol. Sci. 67, 1476 (1978).CrossRefGoogle Scholar
  2. 2.
    Cornish, A.: Indian Annals of Medical Science, 4, 104. Cited by Bently and Trimen (1880), Medicinal Plants, 1, 62 (1857).Google Scholar
  3. 3.
    Ekong, D.E.: Chemistry of the meliacins (limonoids) structure of nimbolide, a new meliacin fromAzadirachta indica, Chem. Commun. 808 (1967).Google Scholar
  4. 4.
    Patel, R.P. and Bhame, M.T.: Chemical composition of some medicinal plants.Indian J. Med. Res. 50, 218 (1962).PubMedGoogle Scholar
  5. 5.
    Arigbabu, S.O. and Don-Pedro, S.G.: Effects ofMelia Azadirach on livestock.Afr. J. Pharmacol. Pharm. Sci. 114, 181 (1971).Google Scholar
  6. 6.
    Tella, A.: Some pharmacological aspects forAzadivachto indica plant.West. Afr. J. Pharmacol. Drug. Res. 3, 80 (1976).Google Scholar
  7. 7.
    Oelrichs, P.B., Hill, M.W., Vallely, P.J., Macleod, J.K. and Malinski, T.F.: Relation between some clinical and histopathological effects ofAzadirachta indica.Phytochem.22, 531 (1983).CrossRefGoogle Scholar
  8. 8.
    Taha, S.A.: Pharmacological studies on the leaves ofAcadirachta indica hypoglycemic activity. Ph.D. Thesis, Univ. of Wales (1973).Google Scholar
  9. 9.
    Haslewood, G.A.P. and Strookman, T.A.: A method for the estimation of true sugar in 0.05 ml blood.Biochem. J. 33, 920 (1939).PubMedGoogle Scholar
  10. 10.
    MacIntyre, I. and Ralston, M.: Direct determination of serum cholesterol.Biochem. J. 56, 1954 (1954).Google Scholar
  11. 11.
    Lowrey, D.H., Rosenbrough, N.G., Farr, I.A. and Randle, R.G.: A method for estimation of tissue proteins,193, 265 (1951).Google Scholar
  12. 12.
    Osborne, D.R. and Voogt, P.: Food Science and Technology. The Analysis of Nutrients in Food. Acad. Press. London (1978).Google Scholar
  13. 13.
    Duncan, D.B.: Multiple Range and Multiple T. Test Biometrics,11, 1 (1955).Google Scholar
  14. 14.
    Teotia, T.P. and Tiwari, G.C.: Toxicity of some important insecticides to the coccinellid predator, coccinella septempunctate.Labdev. J. Sci. Tech. 10B, 17 (1972).Google Scholar
  15. 15.
    Bhat, J.V. and Broker, R.J.: Riboflavine and Thiamine Contents of Sappron (Crocus sativus).Indust. Res. 13B, 305 (1954).Google Scholar

Copyright information

© The Pharmaceutical Society of Korea 1990

Authors and Affiliations

  • Z. M. El-Hawary
    • 1
  • T. S. Kholief
    • 2
  1. 1.Department of NutritionNational Research CentreCairoEgypt
  2. 2.Department of Biochemistry and Nutrition, University College for WomenAin Shams UniversityCairoEgypt

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