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Archives of Pharmacal Research

, Volume 13, Issue 1, pp 108–112 | Cite as

Biochemical studies on hypoglycemic agents (I) effect ofAzadirachta indica leaf extract

  • Z. M. El-Hawary
  • T. S. Kholief
Notes

Abstract

It was confirmed that extracts of some plants were used in folklore medicine as hypoglycemic agents. Of these plants isAzadirachta indica (“neem”), which grows in tropical regions. The present study deals with biochemical effects of the “neem” leaf water extract given orally to experimental animals, especially the hypoglycemic characteristics. Normals as well as alloxan diabetic rats have been used in this work. The results showed that the “neem” leaf extract produced some hypoglycemia in normal rats when given in two doses, while in diabetic rats there was a decrease in blood sugar, but it could not alleviate the diabetic state. However, the “neem” leaf extract produced some toxic effects in rats, as observed that the clotting time of blood was higher than that of the normal. Serum cholesterol level increased with concomitant decrease in the liver fat as compared to normal levels. There was also a drop in liver proteins which was dose-related. The results were compared with those obtained with an oral hypoglycemic drug (Glibenclamide).

Keywords

Diabetes hypoglycemia Azadirachta indica 

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Copyright information

© The Pharmaceutical Society of Korea 1990

Authors and Affiliations

  • Z. M. El-Hawary
    • 1
  • T. S. Kholief
    • 2
  1. 1.Department of NutritionNational Research CentreCairoEgypt
  2. 2.Department of Biochemistry and Nutrition, University College for WomenAin Shams UniversityCairoEgypt

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