Archives of Pharmacal Research

, Volume 14, Issue 1, pp 12–18 | Cite as

Percutaneous absorptoin-enhancing activity of urea derivatives

  • Suk Kyu Han
  • Young Hee Jun
  • Yong Jae Rho
  • Sung Cheul Hong
  • Young Mi Kim
Original Articles


The effect of urea and urea derivatives on the percutaneous absorption of salicylic acid and sodium salicylate through the skin of rabbit from petrolatum ointment was investigated. It was found that addition of urea or urea derivatives to the ointment base significantly increased the percutaneous absorption of the drugs in proportion to the concentratoin of the additive. The percutaneous absorptoin-enhancing activities of these compounds were that urea derivatives with the more and longer alkyl substituents showed the stronger activities. These activities of urea and urea derivatives were ascribed to the binding of these compounds with the lipids and proteins of the stratum corneum of the skin and the swelling of the tissues, which leads to the reduction of the barrier property of the layer. The preliminary skin irritation test showed that urea and urea derivatives were quite non-irritating to the skin. These results suggest that urea derivatives have a strong possibility to be developed as a percutaneous absorption enhancer.

Key words

Percutaneous absorption salicylic acid urea derivatives skin ointment 


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Copyright information

© The Pharmaceutical Society of Korea 1991

Authors and Affiliations

  • Suk Kyu Han
    • 1
  • Young Hee Jun
    • 1
  • Yong Jae Rho
    • 1
  • Sung Cheul Hong
    • 1
  • Young Mi Kim
    • 1
  1. 1.The Research Institute of Pharmaceutical sciences, College of PharmacyPusan National UniversityPusanKorea

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