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Antioxidant activity of resveratrol closely correlates with its monoamine oxidase-A inhibitory activity

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Abstract

Polyhydroxystilbenes including resveratrol were reported to competitively inhibit monoamine oxidase-A without structural relation with substrates and synthetic inhibitors for the enzyme. We attempt to explore a plausible mechanism for their inhibitory activity on MAO-A. All the polyhydroxystilbenes tested showed the antioxidant activity on liver homogenate. Furthermore, the antioxidant activity turned out to closely correlate with the MAO-A inhibitory activity.

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  1. Natural Products Research Institute, Seoul National University, 110-460, Seoul, Korea

    Yong Nam Han, Shi Yong Ryu & Byung Hoon Han

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  1. Yong Nam Han
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  2. Shi Yong Ryu
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  3. Byung Hoon Han
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Han, Y.N., Ryu, S.Y. & Han, B.H. Antioxidant activity of resveratrol closely correlates with its monoamine oxidase-A inhibitory activity. Arch. Pharm. Res. 13, 132–135 (1990). https://doi.org/10.1007/BF02857789

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  • DOI: https://doi.org/10.1007/BF02857789

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