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Archives of Pharmacal Research

, Volume 11, Issue 4, pp 308–311 | Cite as

Effects of some coumarin derivatives on the bovine lens aldose reductase activity

  • Chang-Kiu Moon
  • Se-Chang Lee
  • Yeo-Pyo Yun
  • Bae-Jin Ha
  • Chang-Soo Yook
Original Articles

Abstract

Nine coumarin derivatives were examined for their inhibitory effects on bovine lens aldose reductase activity (bovine-LAR). More than 50% inhibition of BLAR activities was observed in the cases of treatments with decursin, decursinol, esculin, isoimperatorin, oxypeucedanine and isobergapten at the concentration of 10−4M. Especially, BLAR activity was completely inhibited by the treatment of decursin and decursinol at this concentration. At 10−5M, only three coumarins-decursin, decursinol and isoimperatorin, were found to have still relatively higher inhibitory effect.

Keywords

Lens aldose reductase coumarin derivatives 

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Literature Cited

  1. 1.
    Haymann, S. and Kinoshita, J.H.: Isolation and properties of lens aldose reductase.J. Biol. Chem. 240, 877 (1965).Google Scholar
  2. 2.
    Moonsammy, G.I. and Stewart, M.A.: Purification and propertties of brain aldose reductase and L-hexoante dehydrogenase.J. Neurochem. 14, 1187 (1967).PubMedCrossRefGoogle Scholar
  3. 3.
    Gabbay, K.H.: Purification and immunological identification of bovine retinal aldose reductase.Isr. J. Med. Sci. 8, 1626 (1972).PubMedGoogle Scholar
  4. 4.
    Gabbay, K.H. and Cathcart, E.S.: Purification and immunologic identification of aldose reductase.Diabetes 23, 460 (1974).PubMedGoogle Scholar
  5. 5.
    Clements, R.S.J., Weaver, J.P. and Winegrad, A.I.: The distribution of polyol: NADP oxidoreductase in mammalian tissues.Biochem. Biophys. Res. Commun. 37, 347 (1969).PubMedCrossRefGoogle Scholar
  6. 6.
    Clements, R.S. and Winegrad, A.I.: NADP oxidoreductase from human placenta.Biochem. Biophys. Res. Commun. 47, 1473 (1972).PubMedCrossRefGoogle Scholar
  7. 7.
    Kinoshita, J.H., Futterma, S., Satoh, K. and Merola, L.O.: Factors affecting the formation of sugar alcohols in ocular lens.Biochim. Biophys. Acta 74, 340 (1963).PubMedCrossRefGoogle Scholar
  8. 8.
    Schaeff C.M. and Doughty C.C.: Physical and kinetic properties of homogenous bovine lens aldose reductase.J. Biol. Chem. 251, 2696 (1976).Google Scholar
  9. 9.
    Kinoshita, J.H., Mechanisms initiating cataract formation.Invest. Ophhalmol. 13, 713 (1974).Google Scholar
  10. 10.
    Collins, J.G.: Aldose reductase and sorbitol dehydrogenase distribution in substructures of normal and diabetic rat lens.Invest. Opthalmol. 16, 242 (1977).Google Scholar
  11. 11.
    Barber G.W., Human cataractogenesis: a review.Exp. Eye. Res. 16, 85 1973.PubMedCrossRefGoogle Scholar
  12. 12.
    Gabbay, K.H., The sorbitol pathway and the complications of diabetes.New Engl. J. Med. 288, 831 (1973).PubMedGoogle Scholar
  13. 13.
    Varma, S.D.: Inhibition of lens aldose reductase by flavonoids-their possible role in the prevention of diabetic cataracts.Biochemical Pharmacol. 25, 2505 (1976).CrossRefGoogle Scholar
  14. 14.
    Gabbay K.H.: Kinetics of an orally absorbed aldose reductase inhibitor, sorbinil.Clin. Pharm. Ther. 30, 693 (1981).Google Scholar
  15. 15.
    Datiles, M.: Galactose cataract prevention with sorbinil, an aldose reductase inhibitor; light microscopic study.Invest. Opthalmol. 22, 174, (1982).Google Scholar
  16. 16.
    Jedjiniak J.A.: Activators and inhibitors of lens aldose reductase.Invest. Opthalmol. 10, 357 (1971).Google Scholar

Copyright information

© The Pharmaceutical Society of Korea 1988

Authors and Affiliations

  • Chang-Kiu Moon
    • 1
  • Se-Chang Lee
    • 1
  • Yeo-Pyo Yun
    • 2
  • Bae-Jin Ha
    • 3
  • Chang-Soo Yook
    • 4
  1. 1.College of PharmacySeoul Nat'l UniversitySeoulKorea
  2. 2.College of PharmacyChungbuk Nat'l UniversityCheongjuKorea
  3. 3.Department of ChemistryPusan Women's CollegePusanKorea
  4. 4.College of PharmacyKyung Hee UniversitySeoulKorea

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