Archives of Pharmacal Research

, Volume 11, Issue 4, pp 308–311 | Cite as

Effects of some coumarin derivatives on the bovine lens aldose reductase activity

  • Chang-Kiu Moon
  • Se-Chang Lee
  • Yeo-Pyo Yun
  • Bae-Jin Ha
  • Chang-Soo Yook
Original Articles


Nine coumarin derivatives were examined for their inhibitory effects on bovine lens aldose reductase activity (bovine-LAR). More than 50% inhibition of BLAR activities was observed in the cases of treatments with decursin, decursinol, esculin, isoimperatorin, oxypeucedanine and isobergapten at the concentration of 10−4M. Especially, BLAR activity was completely inhibited by the treatment of decursin and decursinol at this concentration. At 10−5M, only three coumarins-decursin, decursinol and isoimperatorin, were found to have still relatively higher inhibitory effect.


Lens aldose reductase coumarin derivatives 


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Copyright information

© The Pharmaceutical Society of Korea 1988

Authors and Affiliations

  • Chang-Kiu Moon
    • 1
  • Se-Chang Lee
    • 1
  • Yeo-Pyo Yun
    • 2
  • Bae-Jin Ha
    • 3
  • Chang-Soo Yook
    • 4
  1. 1.College of PharmacySeoul Nat'l UniversitySeoulKorea
  2. 2.College of PharmacyChungbuk Nat'l UniversityCheongjuKorea
  3. 3.Department of ChemistryPusan Women's CollegePusanKorea
  4. 4.College of PharmacyKyung Hee UniversitySeoulKorea

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