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Archives of Pharmacal Research

, Volume 12, Issue 2, pp 138–142 | Cite as

Synthesis and structure of purine derivatives as antitumor effects

  • H. H. Moharram
  • Khairy A. M. El-Bayouki
  • B. Haggag
  • W. M. Basyouni
  • A. M. Osman
Original Articles
  • 33 Downloads

Abstract

The nucleophilic substitution reaction of 6-chloro purines (I) with malononitrile and ethyl cyanoacetate is carried out in DMSO and in the presence of an alkali. The possible tautomeric-ylidene form for the products is considered and discussed in view of IR, UV, NMR and mass spectral determinations. The derivatives were tested for their antitumor activities.

Keywords

6-Chloro-9-aryl-9H-purines purinylidenes antitumor activity 

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Copyright information

© The Pharmaceutical Society of Korea 1989

Authors and Affiliations

  • H. H. Moharram
    • 1
    • 2
  • Khairy A. M. El-Bayouki
    • 1
    • 2
  • B. Haggag
    • 1
    • 2
  • W. M. Basyouni
    • 1
    • 2
  • A. M. Osman
    • 1
    • 2
  1. 1.National Organisation for Drug Control and ResearchNational Research CenterCairoEgypt
  2. 2.Cancer InstituteCairo UniversityEgypt

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