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Archives of Pharmacal Research

, Volume 9, Issue 2, pp 63–73 | Cite as

Biodegradable polymeric drug delivery systems

  • Seo Young Jeong
  • Sung Wan Kim
Reviews

Abstract

The use of biodegradable polymeric materials as drug carriers is a relatively new dimension in polymeric drug delivery systems. A number of biodegradable or bioerodible polymers, such as poly (lactic/glycolic acid) copolymer, poly(α-amino acid), polyanhydride, and poly (ortho ester) are currently being investigated for this purpose. These polymers are useful for matrix and reservoir-type delivery devices. In addition, when chemical functional groups are introduced to the biodegradable polymer backbone, such as poly (N-(2-hydroxypropy) methacrylamide), the therapeutic agent can be covalently bound directly orvia spacer to the backbone polymer. These polymer/drug conjugates represent another new dimension in biodegradable polymeric drug delivery systems. In this paper, major emphasis is placed on clinical applications of biodegradable polymeric delivery systems. In addition, examples of biodegradable polymeric durg delivery systems currently being investigated will be discussed for the purpose of demonstrating the potential importance of this new field.

Keywords

Drug Release Lactide Drug Delivery System Adriamycin Naltrexone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature Cited

  1. 1.
    S.W. Kim, R.V. Petersen, and J. Feijen, Polymeric Drug Delivery Systems in Drug Design, Ed. by J. Ariens, Academic Press 10: 193 (1980).Google Scholar
  2. 2.
    J. Folkman and D.M. Long,J. Surgical Res., 4: 139 (1964).CrossRefGoogle Scholar
  3. 3.
    K.G. Powers,J. Parasitology., 51, 53 (1965).CrossRefGoogle Scholar
  4. 4.
    F. Bass, R.A. Puridon and J.N. Wiley,Nature, 208, 591 (1965).CrossRefGoogle Scholar
  5. 5.
    D.R. Cowsar, in Controlled Release of Biologically Active Agents. Eds. by A.C. Tranquary and R.E. Lancey, Plenum Press, New York, pp. 1–13 (1974).Google Scholar
  6. 6.
    J.C. McRea and S.W. Kim,Trans. Amer. Soc. Artif. Org., 24, 745 (1978).Google Scholar
  7. 7.
    J.C. McRea, C.D. Ebert, J. Lin and S.W. Kim, in Recent Advances in Drug Delivery Systems, Eds. by J.M. Anderson and S.W. Kim, Plenum Press, New York, pp. 137–151 (1984).Google Scholar
  8. 8.
    “The Progestasert” Monograph, ALZA Corporation, Palo Alto, California (1976).Google Scholar
  9. 9.
    “The Ocusert” Monograph, ALZA Corporation, Palo Alto, California (1974).Google Scholar
  10. 10.
    T.M. Jackanicz, H.A. Nash, D.L. Wise and J.B. Gregory,Contraception, 8, 227 (1973).CrossRefGoogle Scholar
  11. 11.
    R.K. Kulkrani, E.G. Moore, A.F. Hegyeli and F. Leonard,J. Biomed. Mater. Res., 5, 169 (1971).CrossRefGoogle Scholar
  12. 12.
    R.K. Kulkrani, K.C. Pani, C. Neuman and F. Leonard,Arch. Surg., 93, 839 (1966).Google Scholar
  13. 13.
    L.C. Anderson, D.L. Wise and J.F. Howes,Contraception, 13, 375 (1976).PubMedCrossRefGoogle Scholar
  14. 14.
    N. Mason, C. Thies and T.J. Cicero,J. Pharm. Sci., 65, 847 (1976).PubMedCrossRefGoogle Scholar
  15. 15.
    A.D. Schwope, D.L. Wise and J.F. Howes,Life Science, 17, 1877 (1875).CrossRefGoogle Scholar
  16. 16.
    D.L. Wise, J.B. Gregory, P.M. Newberne, L.C. Bartholow and J.B. Stanbury, in Polymeric Delivery systems, Ed. by R.J. Kostelnik, Gordon ad Breach Sci. Pub., New York, pp. 121–138 (1978).Google Scholar
  17. 17.
    D.L. Wise, A.D. Schwope, S.E. Harrigan, D.A. McCarty and J.F. Howes, in Polymeric Delivery Systems, Ed. by R.J. Kostelnik, Gordon and Breach Sci. Put., New York, pp. 75–89 (1978).Google Scholar
  18. 18.
    Annual Report Summary. NICHD, NIH (1976).Google Scholar
  19. 19.
    C.C. Pitt, F.T.R. Jeffcoat, R.A. Zweidinger and A. Schindler,J. Biomed. Mater. Res., 13, 491 (1979).CrossRefGoogle Scholar
  20. 20.
    K.E. Sidmanet al., Research Monograph, Series IV, NIDA, Ed. by R. Willett, p 33 (1976).Google Scholar
  21. 21.
    J. Heller,Biomaterial, 1, 1. 51 (1980).CrossRefGoogle Scholar
  22. 22.
    J. Heller,J. Controlled Rel., 2, 167 (1985).CrossRefGoogle Scholar
  23. 23.
    K.W. Leong, B.C. Brott and R. Langer,Polymer Preprint, 25(1), 201 (1984).Google Scholar
  24. 24.
    K.W. Leong, B.C. Brott and R. Langer,J. Biomed. Mater. Res. in press.Google Scholar
  25. 25.
    K.W. Leong, P. D’Amore, M. Marletta and R. Langer,ibid. J. Biomed. Mater. Res., in press.Google Scholar
  26. 26.
    A. Conix,J. Polymer. Sci., 29, 343 (1958).CrossRefGoogle Scholar
  27. 27.
    L.C. Lappas and W. McKeehan,J. Pharm. Sci., 51, 808 (1962).PubMedCrossRefGoogle Scholar
  28. 28.
    L.C. Lappas and W. McKeehan,ibid.,,54 176 (1965).PubMedCrossRefGoogle Scholar
  29. 29.
    L.C. Lappas and W. McKeehan,ibid.,,56, 1257 (1967).PubMedCrossRefGoogle Scholar
  30. 30.
    J. Heller, R.W. Baker, R.M. Gale and J.O. Rodin,J. Appl. Polymer Sci., 22, 1991 (1978).CrossRefGoogle Scholar
  31. 31.
    J. Heller, B.K. Fritzinger, S.Y. Ng and D.W.H. Penhale,J. Controlled Rel., 1, 225 (1985).CrossRefGoogle Scholar
  32. 32.
    J. Heller, B.K. Fritzinger, S.Y. Ng and D.W.H. Penhale,ibid.,,1, 233 (1985).CrossRefGoogle Scholar
  33. 33.
    J. Heller, D.W.H. Penhale, B.K. Fritzinger and S.Y. Ng, in Long-Acting Contraceptive Delivery Systems, Eds. by G.I. Zatuchiet al., Harper and Row, New York, pp. 113–128 (1984).Google Scholar
  34. 34.
    J. Heller, D.W.H. Penhale and R.F. Helwing,J. Polym. Sci. Polym. Letter. Ed., 18, 619 (1980).CrossRefGoogle Scholar
  35. 35.
    J. Heller, D.W.H. Penhale, B.K. Fritzinger, J.E. Rose and R.F. Helwing,Contracept. Deliv. Syst., 4, 42 (1983).Google Scholar
  36. 36.
    J. Heller, D.W.H. Penhale, R.F. Helwing,Polym. Eng. Sci., 21, 727 (1981).CrossRefGoogle Scholar
  37. 37.
    R.V. Sparer, C. Shih, C.D. Ringeisen and K.J. Himmerlstein,J. Controlled Rel., 1, 23 (1984).CrossRefGoogle Scholar
  38. 38.
    S. Mitra, M. Van Dress, J.M. Anderson, R.V. Petersen, D. Gregonis and J. Feijen,ACS Polym. Prepr., 20(2), 32 (1979).Google Scholar
  39. 39.
    J. Feijen, D. Gregonis, C. Anderson, R.V. Petersen and J. Anderson,J. Pharm. Sci., 69, 871 (1980).PubMedCrossRefGoogle Scholar
  40. 40.
    D. Gregonis, J. Feijen, J. Anderson and R.V. Petersen,ACS Polym. Prep., 20(1) 612 (1979).Google Scholar
  41. 41.
    R.V. Petersen, S.K. Kim, J.M. Anderson, S.M. Fang, D. Gregonis, J. Nelson, D. Coleman, S. Woodward and C. Anderson, Development and Testing of New Biodegradable Drug Delivery System, Contract No. 1-HD-2824, Final Report submitted to NICHD, (Dec. 1980), pp. 1–125.Google Scholar
  42. 42.
    N. Negishi, D.B. Bennett, S.Y. Jeong, W.A.R. Van Heeswijk, J. Feijen and S.W. Kim, submitted toJ. Pharm. Sci. Google Scholar
  43. 43.
    W.A.R. van Heeswijk et al, in Recent Advances in Drug Delivery Systems, Eds. by J.M. Anderson and S.W. Kim, Plenum Press, New York, pp. 77–100 (1984).Google Scholar
  44. 44.
    R.A. De Weger and H.F.J. Dullen,Cancer Immunol. Immunother., 8, 9 (1988).Google Scholar
  45. 45.
    B. Rihova and J. Kopecek,J. Controlled Rel., 2, 289 (1985).CrossRefGoogle Scholar
  46. 46.
    A. Trouet, D. Deprez-de Campeneere and C. De Duve,Nature New Biol., 239, 110 (1972).PubMedCrossRefGoogle Scholar
  47. 47.
    G. Sokal, A. Trouet, J.L. Micheaux and G. Cornu,Europ. J. Canc., 9, 391 (1973).Google Scholar
  48. 48.
    G. Gregoniades and E.D. Neerunjun,Res. Commun. Chem. Pathol. Pharmacol., 10, 351 (1975).Google Scholar
  49. 49.
    T. Ghose, M.R.C. Path and S.P. Nigam,Cancer, 29, 1398 (1972).PubMedCrossRefGoogle Scholar
  50. 50.
    E. Mayhew, D. Papahadjopoulos, Y.M. Rustum and C. Dave,Cancer Res., 36, 4406 (1976).PubMedGoogle Scholar
  51. 51.
    J.N. Weinstein, R. Blumental, S.O. Sharrow and P.A. Henhart,Biochim. Biophys. Acta, 509, 272 (1978).PubMedCrossRefGoogle Scholar
  52. 52.
    K.J. Widdler, A.E. Senyei and B. Sears,J. Pharm. Sci., 71, 379 (1982).CrossRefGoogle Scholar
  53. 53.
    G. Bardanti-Brodano and L. Fiume,Experientia, 30, 1180 (1974).CrossRefGoogle Scholar
  54. 54.
    G.F. Rowland,Europ. J. Canc., 13, 593 (1977).Google Scholar
  55. 55.
    Y. Tsukada, W.K.D. Bischof, N. Hibi, H. Harai, E. Hurwitz and M. Sela,Proc. Natl. Acad. Sci. USA., 79, 621 (1982).PubMedCrossRefGoogle Scholar
  56. 56.
    F. Levi-Schaffer, A. Bernstein, A. Meshorer and R. Arnon,Canc. Treat. Rep., 66, 107 (1982).Google Scholar
  57. 57.
    A. Trouet, M. Masquelier, R. Baurain and D. Deprez-De Campeneere,Proc. Natl. Acad. Sci. USA., 79, 626 (1982).PubMedCrossRefGoogle Scholar
  58. 58.
    J. Lin, J. Li and T. Tung,J. Natl. Cancer Inst., 66, 523 (1981).PubMedGoogle Scholar
  59. 59.
    T. Kitao and K. Hattori,Nature, 265, 81 (1977).PubMedCrossRefGoogle Scholar
  60. 60.
    W.C. Shen and H.J.P. Ryser,Biochem. Biophys. Res. Comm., 102, 1048 (1981).PubMedCrossRefGoogle Scholar
  61. 61.
    M. Monsigny, C. Kieda, A.C. Roche and F. Delmotte,FEBS Lett., 119, 181 (1981).CrossRefGoogle Scholar
  62. 62.
    P. Couvreur, B. Kante, M. Roland and P. Speiser,J. Pharm. Sci., 68, 1521 (1979).PubMedCrossRefGoogle Scholar
  63. 63.
    W.A.R. van Heeswijk, C.J.T. Hoes, T. Stoffer, M.J.D. Eenink, W. Potman and J. Feijen,J. Controlled Rel., 1, 301 (1984).CrossRefGoogle Scholar
  64. 64.
    C.J.T. Hoes, W. Potman, W.A.R. van Heeswijk, J. Mud, B.G. de Grooth, J. Greve and J. Feijen,J. Controlled Rel., 2, 205 (1985).CrossRefGoogle Scholar
  65. 65.
    R. Duncan, J.B. Lloyd and J. Kopecek,Biochem. Biophys. Res. Comm., 94, 284 (1980).PubMedCrossRefGoogle Scholar
  66. 66.
    R. Duncan, P. Rejamnova, J. Kopecek and J.B. Lloyd,Biochim. Biophys. Acta, 678, 143 (1981).PubMedGoogle Scholar
  67. 67.
    R. Duncan, J. Kopecek, P. Rejamnova and J.B. Lloyd,ibid,,775, 518 (1983).Google Scholar
  68. 68.
    B. Rihova, J. Kopecek, K. Ulbrich, M. Pospisil and P. Mancal,Biomaterials, 5, 143 (1984).PubMedCrossRefGoogle Scholar
  69. 69.
    B. Rihova, J. Kopecek, K. Ulbrich, V. Chytry,Makromol. Chem., Suppl. 9, 13 (1985).CrossRefGoogle Scholar
  70. 70.
    J. Kopecek, in Recent Advances in Drug Delivery Systms, Eds. by J.M. anderson and S.W. Kim, Plenum Press, New York, pp. 41–62 (1984).Google Scholar
  71. 71.
    R. Duncan and J. Kopecek,Adv. Polym. Sci., 57, 41 (1984).Google Scholar
  72. 72.
    J. Kopecek, in IUPAC Macromolecules, Eds. by H. Benoit and P. Rempp Pergamon Press, Oxford, pp. 305–320 (1982).Google Scholar
  73. 73.
    R. Duncan, H.C. Cable, J.B. Lloyd, P. Rejmanova and J. Kopecek,Biosci. Rep., 2, 1041 (1982).PubMedCrossRefGoogle Scholar
  74. 74.
    P. Rejmanova, J. Kopecek, R. Duncan and J.B. Lloyd,Biomaterials, 6, 45 (1985).PubMedCrossRefGoogle Scholar
  75. 75.
    K. Ulbrich, J. Stohalm and J. Kopecek,Makromol. Chem., 182, 1917 (1981).CrossRefGoogle Scholar
  76. 76.
    J. Kopecek, P. Rejmanova and V. Chytry,ibid., 182, 799 (1981).CrossRefGoogle Scholar
  77. 77.
    P. Rejmanova, B. Obereigner and J. Kopecek,ibid.,,182, 1899 (1981).CrossRefGoogle Scholar

Copyright information

© The Pharmaceutical Society of Korea 1986

Authors and Affiliations

  • Seo Young Jeong
    • 1
  • Sung Wan Kim
    • 1
  1. 1.Department of Pharmaceutics and Center for Controlled Chemical DeliveryUniverisy of UtahSalt Lake CityUSA

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