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Acta Academiae Medicinae Wuhan

, Volume 4, Issue 1, pp 61–64 | Cite as

Cytogenetic study in acute myelocytic leukemia M2

  • Liu Shu-mao
  • Yang Ai-de
  • Yan Ju
  • Fei Hong-bao
  • He Mei-juan
  • Wang Bian-ming
Article
  • 12 Downloads

Summary

Cytogenetic studies were made in 22 patients with acute myelocytic leukemia (AML) (M2), in 12 of whom the banding analysis was satisfactory. 4 of these 12 cases (33.3%) were proved to have 8;21 translocation, among whom one was an adult and the other 3 children. 2 male patients showed loss of Y chromosome and the karyotype was 45,X,-Y,t(8q, 2lq+); one female patient showed an additional structural rearrangement and the karyotype was 46,XX, t(8q,21q+),t(3p:11p+). Out of the 4 patients with t(8;2l) 2 achieved complete or partial remission after treatment and the remission rate was about 50%. The period of survival in these two patients was also longer. They were still alive 12 months after the establishment of the diagnosis. The other 2 patients lived only 1.5–2 months. The short period of survival was probably due to loss of Y chromosome.

Key words

leukemia cytogenetics chromosome 

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Copyright information

© Wuhan Medical College 1984

Authors and Affiliations

  • Liu Shu-mao
    • 1
  • Yang Ai-de
    • 1
  • Yan Ju
    • 1
  • Fei Hong-bao
    • 1
  • He Mei-juan
    • 1
  • Wang Bian-ming
    • 1
  1. 1.Research Department of Hematology, 1st Teaching HospitalWuhan Medical CollegeWuhan

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