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Identfiication of N-acetyl and hydroxylated N-acetyltranylcypromine from tranylcypromine-dosed rat urine

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Abstract

Mechanism of the monoamine oxidase inhibition by tranylcypromine was studied in relation to its metabolism to reactive species. A metabolic study performed to collect general biotransformation pathway in rats provided GC/MS evidence for the detection of two new metabolites, N-acetyl and hydroxylated N-acetyltranylcypromine.

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Literature Cited

  1. Kang, G. I.: Mechanism of the Monoamine Oxidase Inhibition.Yakhak Hoeji 27, 321 (1983).

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  2. Paech, C. P., Salach, J. I., and Singer, T. P.: Suicide Inactivation of Monoamine Oxidase by trans-Phenylcyclopropylamine.J. Biol. Chem. 255, 2700 (1980).

    PubMed  CAS  Google Scholar 

  3. Fuller, R.W., Hemrick-Luecke, S.K., Molloy, B.B.: N-[2-(o-iodophenoxy) ethyl] cyclopropylamine hydrochloride (LY 121768), A potent and selective irresversible inhibitor of type A monoa-mine oxidase.Biochem. Pharmacol. 32, 1243 (1983).

    Article  PubMed  CAS  Google Scholar 

  4. Neal, R. A.: Chemically Reactive Metabolites as Suicide Enzyme Inhibitors.Drug Metab. Rev. 14, 49 (1983).

    Article  PubMed  CAS  Google Scholar 

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  1. College of Pharmacy, Sookmyung Women’s University, 140, Seoul, Korea

    Gun Il Kang & Soon Young Chung

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  1. Gun Il Kang
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  2. Soon Young Chung
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Mechanism of the Monoamine Oxidase Inhibition I

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Kang, G.I., Chung, S.Y. Identfiication of N-acetyl and hydroxylated N-acetyltranylcypromine from tranylcypromine-dosed rat urine. Arch. Pharm. Res. 7, 65–68 (1984). https://doi.org/10.1007/BF02856926

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  • DOI: https://doi.org/10.1007/BF02856926

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