A survey of the response of Korean medicinal plants on drug metabolism

  • Won Sick Woo
  • Kuk Hyun Shin
  • In Chull Kim
  • Chung Kyu Lee
Original Articles


Alcohol extracts of plants widely used in the traditional medicine have been tested to establish if they affect the metabolism of drugs in mice.

Fourteen of the plants tested exhibited prolonging and/or inhibitory effect on hexobarbital sleeping time. Some of them also showed increasing effect on strychnine mortality, whereasPiperis retrofracti Fructus reduced the toxicity of strychnine.


Korean medicinal plants Hexobarbital hypnosis Strychnine mortality Inhibition and induction of drug metabolizing enzyme 

Literature Cited

  1. 1).
    Eriksson, M., and Yagge, S. F., Drug metabolism in the newborn.Ann. Rev. Med. 24, 29(1973).PubMedCrossRefGoogle Scholar
  2. 2).
    Conney, A. H., Pharmacological implications of microsomal enzyme induction.Pharmacol. Rev. 19, 317(1967).PubMedGoogle Scholar
  3. 3).
    Wattenberg, L. W., Dietary modification of intestinal and pulmonary aryl hydrocarbon hydroxylase activity.Toxicol. Appl. Pharmacol. 23, 741(1972).PubMedCrossRefGoogle Scholar
  4. 4).
    Campbell, T. C., and Hayes, J. R., Role of nutrition in the drug-metabolizing enzyme system.Pharmacol. Rev. 26, 171(1974).PubMedGoogle Scholar
  5. 5).
    Boulos, B. M., Short, C. R., and Davis, L. E., Quinine and quinidine as inhibitors of hepatic microsomal enzymes in the mouse and rat.Fed. Proc. 28, 418(1969).Google Scholar
  6. 6).
    Wattenberg, L. W., Page, M. A., and Leong, J. L., Induction of increased benzpyrene hydroxylase activity by flavones and related compounds.Cancer Res. 28, 934(1968).PubMedGoogle Scholar
  7. 7).
    Jondorf, W. R., Johnson, R. K., and Donahue, J. D., Studies on drug-metabolizing enzyme activity in rats pretreated with phenobarbitone and compounds related to emetine.Biochem. J. 113, 10p (1969).Google Scholar
  8. 8).
    Jondorf, W. R., Johnson, R. K., and Drassner, J. D., The inhibiting influence of emetine and 2,3-dehydroemetine on liver microsomal drug metabolism in the rat.Fed. Proc. 28, 418(1969).Google Scholar
  9. 9).
    Jori, A., Bianchetti, A., and Prestini, P. E., Effect of essential oils on drug metabolism.Biochem. Pharmacol. 18, 2081(1969).PubMedCrossRefGoogle Scholar
  10. 10).
    Parke, D. V., and Rahman, H., The effects of some terpenoids and other dietary anutrients on hepatic drug-metabolizing enzymes.Biochem. J. 113, 12p (1969).Google Scholar
  11. 11).
    Ruddon, R. W. and Cohen, A. M., Alteration of enzyme activity in rat liver after nicotine administration.Fed. Proc. 28, 418(1969).Google Scholar
  12. 12).
    Graham, P. S., Hellyer, R. O., and Ryan, A. J., The inhibition of drug metabolism enzymes by some naturally occurring compounds.Biochem. Pharmacol. 19, 759(1970).PubMedCrossRefGoogle Scholar
  13. 13).
    Graham, P. S., Hellyer, R. O., and Ryan, A. J., The kinetics of inhibition of drug metabolismin vitro by some naturally occurring compounds.Biochem. Pharmacol. 19, 769(1970).PubMedCrossRefGoogle Scholar
  14. 14).
    Parke, D. V., and Rahman, H., Induction of hepatic microsomal enzymes by safrole.Biochem. J. 119, 53p(1970).Google Scholar
  15. 15).
    Wattenberg, L. W., and Leong, J. L., Inhibition of the carcinogenic action of benzo(a)pyrene by flavones.Cancer Res. 30, 1922(1970).PubMedGoogle Scholar
  16. 16).
    Leibman, K. C., Studies on modifiers of microsomal drug oxidation.Chem. Biol. Interactions 3, 289(1971).CrossRefGoogle Scholar
  17. 17).
    Parke, D. V., and Rahman, H., Induction of a new hepatic microsomal hemoprotein by safrole and isosafrole.Biochem. J. 123, 9p(1971).Google Scholar
  18. 18).
    Lake, B. G., and Parke, D. V., Interaction of safrole and isosafrole with hepatic microsomal hemoproteins.Biochem. J. 127, 23p(1972).Google Scholar
  19. 19).
    Witschi, H., and Saint-Francois, B., Enhanced activity of benzpyrene hydroxylase in rat liver and lung after acute cannabis administration.Toxicol. Appl. Pharmacol. 23, 165(1972).PubMedCrossRefGoogle Scholar
  20. 20).
    Berlin, C. M., Stackman, J. M., and Vesell, E. S., Quinine-induced alterations in drug disposition,Clin. Pharmacol. Ther. 18, 670(1975).PubMedGoogle Scholar
  21. 21).
    Ariyoshi, T., Arakaki, M., Ideguchi, K., Ishizuka, Y., Nada, K., and Ide, H., Studies on the metabolism of α-limonene (p-mentha-1,8-diene). III. Effects of α-limonene on the lipids and drug-metabolizing enzymes in rat livers.Xenobiotica 5, 33(1975).PubMedCrossRefGoogle Scholar
  22. 22).
    Conney, A. H., Davidson, C., Gastel, R., and Burns, J. J., Adaptive increases in drug-metabolizing enzymes induced by phenobarbital and other drugs.J. Pharmacol. Exptl. Therap. 130, 1(1960).Google Scholar
  23. 23).
    Kato, R., Chiesara, E., and Vassanelli, P., Further studies on the inhibition and stimulation of microsomal drug-metabolizing enzymes of rat liver by various compounds.Biochem. Pharmacol. 13, 69(1964).PubMedCrossRefGoogle Scholar
  24. 24).
    Gilette, J. R., and Mitchell, J. R., Drug actions and interactions. Theoretical considerations.Handb. Exp. Pharmacol. 28, 359(1975).Google Scholar
  25. 25).
    Adamson, R. H., and Fouts, J. R., Enzymatic-metabolism of strychnine.J. Pharm. Exp. Ther. 127, 87(1959).Google Scholar

Copyright information

© The Pharmaceutical Society of Korea 1978

Authors and Affiliations

  • Won Sick Woo
    • 1
  • Kuk Hyun Shin
    • 1
  • In Chull Kim
    • 1
  • Chung Kyu Lee
    • 1
  1. 1.Natural Products Research InstituteSeoul National UniversitySeoulKorea

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