The AAPS Journal

, Volume 8, Issue 2, pp E409–E412 | Cite as

2-Arachidonoylglycerol (2-AG) membrane transport: History and outlook

  • Anita Hermann
  • Martin Kaczocha
  • Dale G. Deutsch


Only a few studies have addressed the transport of 2-arachidonoylglycerol (2-AG), a naturally occurring agonist for cannabinoid receptors. Based upon saturation kinetics, these early reports have proposed that 2-AG enters the cell by a specific 2-AG transporter, via the putative anandamide transporter, or by simple diffusion. In this review, the uptake of 2-AG is discussed in light of the recent advances that have been made for anandamide transport, where the mechanism appears to be rate-limited diffusion through the membrane. Endocannabinoids may be a distinct class of agonists since they are hydrophobic and neutral, exhibiting similar biophysical properties to some anesthetics that freely diffuse through the membrane.


anandamide 2-AG 2-arachidonoylglycerol cannabinoids endocannabinoid transport 


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Copyright information

© American Association of Pharmaceutical Scientists 2006

Authors and Affiliations

  • Anita Hermann
    • 1
  • Martin Kaczocha
    • 1
  • Dale G. Deutsch
    • 1
  1. 1.Department of Biochemistry and Cell BiologyState University of New York at Stony BrookStony Brook

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