Inhibition of acetyl cholinesterase by solanaceous glycoalkaloids and alkaloids
- 130 Downloads
Seven solanaceous glycoalkaloids (α-chaconine, β2-chaconine, α-solanine, dehydrocommersonine, commersonine, demissine and tomatine) and three alkaloids (solanidine, tomatidine and demissidine) were tested for their ability to inhibit acetyl cholinesterase in anin vitro system. Glycoalkaloids at concentrations of 33–41 parts per million (ppm) gave cholinesterase inhibition ranging from 4.2 to 26.8%. All three alkaloids had lower anticholinesterase (4.2 to 15.4%) than the seven glycoalkaloids, except for tomatine. Two well-known cholinesterase inhibitors, carbaryl, a carbamate insecticide and Guthion, an organophosphate insecticide, were also tested for comparison. It required only 1 to 2 ppm of the insecticides to give the same average percent inhibition as was observed with the glycoalkaloids at concentrations of 33–35 ppm.
Key WordsSolanaceae cholinesterase Colorado potato beetle
Unable to display preview. Download preview PDF.
- 3.Bushway, R.J. 1983. Sources of alkaloid and glycoalkaloid standards for potato breeding programs and other research. Am Potato J 60:793–797.Google Scholar
- 7.McMillan, M. and J.C. Thompson. 1979. An outbreak of suspected solanine poisoning in schoolboys: examination of criteria of solanine poisoning. Quart J Med 190:227–235.Google Scholar
- 9.Orgell, W.H. and E.T. Hibbs. 1963. Human plasma cholinesterase inhibitionin vitro by extracts from tuber-bearingSolanum species. Am Society Hortic Sci 83:651–656.Google Scholar
- 11.Wilson, G.S. 1959. A small outbreak of solanine poisoning. Mon Bull Minist Health Lab Serv Directed Med Res Counc 18:207–210.Google Scholar