American Potato Journal

, Volume 64, Issue 8, pp 409–413 | Cite as

Inhibition of acetyl cholinesterase by solanaceous glycoalkaloids and alkaloids

  • Rodney J. Bushway
  • Sharon A. Savage
  • Bruce S. Ferguson
Short Communication

Abstract

Seven solanaceous glycoalkaloids (α-chaconine, β2-chaconine, α-solanine, dehydrocommersonine, commersonine, demissine and tomatine) and three alkaloids (solanidine, tomatidine and demissidine) were tested for their ability to inhibit acetyl cholinesterase in anin vitro system. Glycoalkaloids at concentrations of 33–41 parts per million (ppm) gave cholinesterase inhibition ranging from 4.2 to 26.8%. All three alkaloids had lower anticholinesterase (4.2 to 15.4%) than the seven glycoalkaloids, except for tomatine. Two well-known cholinesterase inhibitors, carbaryl, a carbamate insecticide and Guthion, an organophosphate insecticide, were also tested for comparison. It required only 1 to 2 ppm of the insecticides to give the same average percent inhibition as was observed with the glycoalkaloids at concentrations of 33–35 ppm.

Key Words

Solanaceae cholinesterase Colorado potato beetle 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    Abbott, D.C., K. Field and E.I. Johnson. 1960. Observations on the correlation of anticholinesterase effect with solanine content of potatoes. Analyst 85:375–376.CrossRefGoogle Scholar
  2. 2.
    Allen, R.J., R.J. Marlar, G.F. Chesney, J.P. Helgeson, A. Kelman, K.G. Weckel, E. Traisman and J.W. White, Jr. 1977. Teratogenicity studies on late blighted potatoes in nonhuman primates (Macaca mulatta andSaghinus labiatus). Teratology 15:17–24.PubMedCrossRefGoogle Scholar
  3. 3.
    Bushway, R.J. 1983. Sources of alkaloid and glycoalkaloid standards for potato breeding programs and other research. Am Potato J 60:793–797.Google Scholar
  4. 4.
    Bushway, R.J., E.S. Barden, A.W. Bushway and A.A. Bushway. 1980. The mass extraction of potato glycoalkaloids from blossoms. Am Potato J 57:175–180.CrossRefGoogle Scholar
  5. 5.
    Keeler, R.F., D. Brown, D.R. Douglas, G.F. Stallknecht and S. Young. 1976. Teratogenicity of theSolanum alkaloid Solasodine and of “Kennebec” potato sprouts in hamsters. Bull Environ Contam Toxicol 15:522–524.PubMedCrossRefGoogle Scholar
  6. 6.
    MacKenzie, J.D. and P. Gregory. 1979. Evaluation of a comprehensive method for total glycoalkaloid determination. Am Potato J 56:27–33.CrossRefGoogle Scholar
  7. 7.
    McMillan, M. and J.C. Thompson. 1979. An outbreak of suspected solanine poisoning in schoolboys: examination of criteria of solanine poisoning. Quart J Med 190:227–235.Google Scholar
  8. 8.
    Mun, A.M., E.S. Barden, J.M. Wilson and J.M. Morgan. 1975. Teratogenic effects in early chick embryos of solanine and glycoalkaloids from potatoes infected with late blight,Phytophthora infestans. Teratology 11:73–77.PubMedCrossRefGoogle Scholar
  9. 9.
    Orgell, W.H. and E.T. Hibbs. 1963. Human plasma cholinesterase inhibitionin vitro by extracts from tuber-bearingSolanum species. Am Society Hortic Sci 83:651–656.Google Scholar
  10. 10.
    Orgell, W.H., K.A. Valdya and P.A. Dahm. 1958. Inhibition of human plasma cholinesterasein vitro by extracts of solanaceous plants. Science 128:1136–1137.PubMedCrossRefGoogle Scholar
  11. 11.
    Wilson, G.S. 1959. A small outbreak of solanine poisoning. Mon Bull Minist Health Lab Serv Directed Med Res Counc 18:207–210.Google Scholar
  12. 12.
    Willimot, S.C. 1933. An investigation of solanine poisoning. Analyst 58:431–439.CrossRefGoogle Scholar

Copyright information

© Springer 1987

Authors and Affiliations

  • Rodney J. Bushway
    • 1
  • Sharon A. Savage
    • 2
  • Bruce S. Ferguson
    • 3
  1. 1.Dept. of Food ScienceUniversity of MaineOrono
  2. 2.Penobscot Valley High SchoolHowland
  3. 3.Biddeford

Personalised recommendations