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Advances in Therapy

, Volume 18, Issue 5, pp 230–236 | Cite as

Carob pulp preparation for treatment of hypercholesterolemia

  • H. J. F. Zunft
  • W. Lüder
  • A. Harde
  • B. Haber
  • H. -J. Graubaum
  • J. Gruenwald
Article

Abstract

The lipid-lowering effect of a carob pulp preparation rich in insoluble dietary fiber and polyphenols was investigated in a noncomparative, open-label pilot study. Over 8 weeks, 47 volunteers with moderate hypercholesterolemia (total cholesterol 232–302 mg/dL) consumed 15 g of carob per day in three products (breakfast cereal, fruit muesli bar, powdered drink) as a supplement to their regular diet. After 4 weeks, reductions of 7.1% in mean total cholesterol and 10.6% in LDL cholesterol were noted; respective decreases after 6 weeks were 7.8% and 12.2% (all P<.001). HDL cholesterol and triglyceride levels remained unchanged. Overall compliance was good. Only 3 volunteers (6%) reported a sensation of fullness, which led to 2 of the 3 dropouts. The carob preparation may have value in the dietary treatment of hypercholesterolemia.

Keywords

hypercholesterolemia dietary fiber carob fiber polyphenols cholesterol lowering 

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Copyright information

© Health Communications Inc 2001

Authors and Affiliations

  • H. J. F. Zunft
    • 1
  • W. Lüder
    • 2
  • A. Harde
    • 3
  • B. Haber
    • 4
  • H. -J. Graubaum
    • 5
  • J. Gruenwald
    • 5
  1. 1.Institute for Nutritional ScienceUniversity of PotsdamGermany
  2. 2.German Institute of Human NutritionBergholz-RehbrueckeGermany
  3. 3.Center for Conventional Medicine & Alternative TherapiesBerlinGermany
  4. 4.Nutrinova Nutrition Specialties & Food Ingredients GmbHFrankfurt/MainGermany
  5. 5.PhytoPharm ConsultingInstitute for Phytopharmaceuticals GmbHBerlinGermany

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