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Inhibition of experimental autoimmune orchitis by fossil diatoms

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Abstract

Experimental autoimmune orchitis (EAO) induced in Swiss mice could be reduced by means of the utilization of micronized frustules of fossil diatoms (DS) containing 54% of SiO2. Experimental mice were sensitized with testicular Antigen (Ag) in Complete Freund’s Adjuvant (CFA) inoculated twice, on day 0 and day 21. 100 μg of DS suspension was inoculated into sensitized mice 10 times, once every 4 days, subcutaneously, starting on day 7 after the first Ag inoculation. Mice receiving the DS treatment showed a diminution of the delayed hypersensitivity reaction, lower antibody titer and decreased incidence of testicular injury as well as reduced grade and extension of the lesions. Possible explanation of these results would suggest alteration of monocyte and/or macrophage normal behaviour as well as alteration of antibody synthesis by different mechanisms.

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Authors and Affiliations

  1. PLEX-CONICET, Instituto de Investigaciones Hematológicas Academia Nacional de Medicina, Las Heras 3092, 1425, Buenos Aires, Argentina

    Oscar D. Bustuoabad & Alejandro M. S. Mayer

  2. Centro de Estudios Oncológicos, Academia Nacional de Medicina, Las Heras 3092, 1425, Buenos Aires, Argentina

    Roberto P. Meiss & Alfredo R. Molinolo

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  1. Oscar D. Bustuoabad
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  2. Roberto P. Meiss
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  3. Alfredo R. Molinolo
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  4. Alejandro M. S. Mayer
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Bustuoabad, O.D., Meiss, R.P., Molinolo, A.R. et al. Inhibition of experimental autoimmune orchitis by fossil diatoms. Chin. J. Ocean. Limnol. 3, 23–29 (1985). https://doi.org/10.1007/BF02852899

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