Inhibition of experimental autoimmune orchitis by fossil diatoms

  • Oscar D. Bustuoabad
  • Roberto P. Meiss
  • Alfredo R. Molinolo
  • Alejandro M. S. Mayer


Experimental autoimmune orchitis (EAO) induced in Swiss mice could be reduced by means of the utilization of micronized frustules of fossil diatoms (DS) containing 54% of SiO2. Experimental mice were sensitized with testicular Antigen (Ag) in Complete Freund’s Adjuvant (CFA) inoculated twice, on day 0 and day 21. 100 μg of DS suspension was inoculated into sensitized mice 10 times, once every 4 days, subcutaneously, starting on day 7 after the first Ag inoculation. Mice receiving the DS treatment showed a diminution of the delayed hypersensitivity reaction, lower antibody titer and decreased incidence of testicular injury as well as reduced grade and extension of the lesions. Possible explanation of these results would suggest alteration of monocyte and/or macrophage normal behaviour as well as alteration of antibody synthesis by different mechanisms.


Delay Type Hypersensitivity Swiss Mouse Orchitis Delay Type Hypersensitivity Reaction Delay Hypersensitivity Reaction 
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Copyright information

© Science Press 1985

Authors and Affiliations

  • Oscar D. Bustuoabad
    • 1
  • Roberto P. Meiss
    • 2
  • Alfredo R. Molinolo
    • 2
  • Alejandro M. S. Mayer
    • 1
  1. 1.PLEX-CONICETInstituto de Investigaciones Hematológicas Academia Nacional de MedicinaBuenos AiresArgentina
  2. 2.Centro de Estudios OncológicosAcademia Nacional de MedicinaBuenos AiresArgentina

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