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Journal of Zhejiang University-SCIENCE A

, Volume 4, Issue 6, pp 749–752 | Cite as

Study of apolipoprotein E genetic polymorphism in patients with atherosclerotic cerebral infarction

  • Luo Ben-yan
  • Chen Zhi
  • Chen Feng
  • Li Xia
  • Pan Xiao-ping
Medicine
  • 30 Downloads

Abstract

Objective: to explore the frequency and significance of ApoE gene polymorphisms in Chinese patients with atherosclerotic cerebral infarction (ACI). Methods: Polymerase chain reaction and gene sequencing, single nucleotide polymorphisms of ApoE gene were used to analyze 33 cases of patients with ACI and 35 controls. Results: The frequencies of ApoE gene single nucleotide polymorphisms 465C/G, 462C/G and 451 delC in the ACI group were significantly higher than those in the control group (P<0.05). The prevalence of polymorphism 486G/T in the control group was significantly higher than that in the ACI group (P=0.011). Conclusions: 465C/G, 462C/G and 451 delC polymorphisms might be associated with ACI. 486GT allale might have protective effect on the pathogenesis of ACI.

Key words

Cerebral infraction Atherosclerotic Genetics ApoE allele Single nucleotide polymorphism 

Document

CLC number

R743 

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Copyright information

© Zhejiang University Press 2003

Authors and Affiliations

  • Luo Ben-yan
    • 1
  • Chen Zhi
    • 2
  • Chen Feng
    • 2
  • Li Xia
    • 1
  • Pan Xiao-ping
    • 2
  1. 1.Department of Neurology, The First Affiliated Hospital, Medical CollegeZhejiang UniversityHangzhouChina
  2. 2.Institute of Infectious Diseases, The First Affiliated Hospital, Medical CollegeZhejiang UniversityHangzhouChina

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