Wuhan University Journal of Natural Sciences

, Volume 9, Issue 6, pp 962–966 | Cite as

Respective roles of short-and long-range interactions in protein folding



A new method was presented to discuss the respective roles of short- and long-range interactions in protein folding. It's based on an off-lattice model, which is also being called as toy model. Simulated annealing algorithm was used to search its native conformation. When it is applied to analysis proteins 1agt and 1aho, we find that helical segment cannot fold into native conformation without the influence of long-range interactions. That's to say that long-range interactions are the main determinants in protein folding.

Key words

toy model protein folding simulated annealing algorithm short and long range interactions 

CLC number

O 242.28 Q71 


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Copyright information

© Springer 2004

Authors and Affiliations

  • Wang Long-hui
    • 1
  • Hu Min
    • 2
  • Zhou Huai-bei
    • 1
  • Liu Juan
    • 1
  1. 1.School of Computer ScienceWuhan UniversityWuhan, HubeiChina
  2. 2.Wuhan University Journals PressWuhan UniversityWuhan, HubeiChina

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