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Advances in Therapy

, Volume 20, Issue 1, pp 43–49 | Cite as

Efficacy of a herbal preparation in patients with functional dyspepsia: A meta-analysis of double-blind, randomized, clinical trials

  • Karl-Josef Gundermann
  • Erhard Godehardt
  • Marianne Ulbrich
Article

Abstract

A meta-analysis was performed of double-blind, randomized clinical studies that evaluated the efficacy of the herbal preparation Iberogast in patients with functional dyspepsia. All studies had the same duration and used the same dosage of active treatment and the same primary outcome measure, a dyspepsia-specific gastrointestinal symptom score. Of the 592 trial participants, 196 were treated with Iberogast and 192 with placebo or cisapride (positive control). The individual studies all showed a substantial improvement of symptoms with Iberogast but varying results regarding its statistically significant superiority to placebo. The meta-analysis of all studies, however, demonstrated a clear, highly significant overall therapeutic effect of Iberogast in the treatment of functional dyspepsia. Tolerability of the preparation was excellent.

Keywords

meta-analysis functional dyspepsia gastrointestinal symptom score 

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Copyright information

© Health Communications Inc 2003

Authors and Affiliations

  • Karl-Josef Gundermann
    • 1
  • Erhard Godehardt
    • 2
  • Marianne Ulbrich
    • 3
  1. 1.Department of Pharmacology and Toxicology Chair of PharmacologyPomeranian Medical AcademySzczecinPoland
  2. 2.Department of Thoracic and Cardiovascular Surgery Section of BiostatisticsHeinrich Heine UniversityDüsseldorfGermany
  3. 3.CologneGermany

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