Evaluation of bone mineral density in children with diabetes mellitus
- 87 Downloads
Multiple studies have documented reduction in peripheral bone mass in children with insulin dependent diabetes mellitus (IDDM). In this study, the bone mineral density (BMD) of the lumbar vertebrae (L2–L4) was measured by dual photon absorptiometry in 14 female and 16 male diabetic patients of age 11 to 16 years with varying clinical duration. Twenty three children between 11 to 16 years with normal anthropometric measurements between 10th and 97th percentile and no known history of metabolic bone disease served as a control group. BMD values, weight, height, body mass index, metabolic, biochemical and growth parameters of the study group were compared with those of the control group. BMD (L2 AP 0.732±0.15 gm/cm2, L2 lateral 0.534 ±0.09 gm/cm2in the study group and 0.812±0.63 gm/cm2 and 0.619±0.20 gm/cm2 in the control group) and osteoccalcin (10.10±3.40 ng/ml and 23.12±2.74 ng/ml in diabetes and control respectively) levels were significantly lower in diabetic patients (p<0.05, p<0.01 respectively). Within the study group BMD correlated positively with age but not with the duration of the disease nor with the level of metabolic control.
Key wordsBone mineral density Insulin dependent diabetes mellitus
Unable to display preview. Download preview PDF.
- 3.Stephan WP, David PM, Daniel F, Judy LP, Margaret GM, Ben HB. Spinal bone mineral density in children aged 5.00 through 11.99 years.AJDC 1990; 144: 1346–1348.Google Scholar
- 4.Siu LH, Solomon E, Conrad CJ. A prospective study of bone mass in patients with type 1 diabetes.J Clin Endocrinol Metab 1985; 60: 74–80.Google Scholar
- 5.Catherine G, Pierre B, Louis D, Pierre C, Pierre JM, Pierre DD. Measurement of bone mineral content of the lumbar spine by dual energy X-ray absorptiometry in normal children. Correlations with growth parameters.J Clin Endocrinol Metab 1990; 70: 1330–1333.Google Scholar
- 10.Scott D, Robins SP, Nicol P, Chen XB, Buchan W. Effects of low phoshate intake on bone mineral metabolism and microbial protein systhesis in lambs.Exp Physicol 1994; 79 (2): 183–187.Google Scholar
- 12.Juul A, Dagaard P, Blum FWet al. Serum levels of Insulin-like growth factor (IGF) Binding protein-3 (IGFBP-3) in healthy infants, children and adolescent. The relation to IGF-1, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation.J Clin Endoc Metab 1995; 80 (8): 2534–2542.CrossRefGoogle Scholar
- 13.McNair P, Madsbad S, Christensen MSet al. Hypoparathyroidism in diabetes mellitus.Acta Endocronologica 1981; 96: 81–86.Google Scholar
- 15.Hough FS. Alterations of bone and mineral metabolism in diabetes mellitus.SAMJ 1987; 80: 120–126.Google Scholar
- 18.Forest MG. Adrenal steroid excess.Clinical Paediatric Endocrinology. Brook (ed), Blackwell science. Third Edition 1995; p. 499–535.Google Scholar
- 19.Johnston CC, Slemenda CW, Melton JL. Clinical use of bone densitometry.N Eng J Metabol 1991; 324 (16): 1105–1109.Google Scholar