Structure activity studies on the phenolic substrates in microsomal hydroxylation
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Quantitative structure-activity relationships have been developed for three series of phenolic substrates viz. phenols, hydroxyindoles and tyramines in microsomal hydroxylation. The Fujita-Ban group contributions of various substituents have been calculated. Mono-, bi-and tri-substituted phenols have been investigated in the light of the linear free energy related model also.
KeywordsQuantitative structure-activity relationships Fujita-Ban group contributions Hansch analysis phenolic substrates microsomal hydroxylation
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