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Structure activity studies on the phenolic substrates in microsomal hydroxylation

  • Harkishan Singh
  • Vijay Gombar
  • D. V. S. Jain
Physical and Theoretical

Abstract

Quantitative structure-activity relationships have been developed for three series of phenolic substrates viz. phenols, hydroxyindoles and tyramines in microsomal hydroxylation. The Fujita-Ban group contributions of various substituents have been calculated. Mono-, bi-and tri-substituted phenols have been investigated in the light of the linear free energy related model also.

Keywords

Quantitative structure-activity relationships Fujita-Ban group contributions Hansch analysis phenolic substrates microsomal hydroxylation 

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Copyright information

© Indian Academy of Sciences 1980

Authors and Affiliations

  • Harkishan Singh
    • 1
    • 2
  • Vijay Gombar
    • 1
    • 2
  • D. V. S. Jain
    • 1
    • 3
  1. 1.Panjab UniversityChandigarh
  2. 2.Department of Pharmaceutical SciencesIndia
  3. 3.Department of ChemistryIndia

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