Abstract
The preparation method of urethral extracellular matrix (ECM) was introduced and the biocompatibility of urethral ECM was studied. The urethral segmental defect was created artificially in animal models, which were followed by reconstruction with prepared urethral ECM. And postoperative histologic and pathologic exams were employed to evaluate the biocompatibility of urethral ECM. The experimental results show that urethral ECM was biocompatible and can promote cellular interaction as well as tissue development. Urethrography and urodynamic evaluation revealed that there was no difference between the normal and new tissue. The urethral ECM appears to be a useful material for urethral repair in the rabbit. It is biocompatible and for tissue handling.
Similar content being viewed by others
References
Atala A. Regenerative medicine and Urology.BJU International, 2003, 92 (Suppl.):58–67
Shin H, Seongbong J, Antonios G M. Biomimetic Materials for Tissue Engineering.Biomaterials, 2003, 24:4353–4364
Kim B S, Baez C E, Atala A. Biomaterials for Tissue Engineering.World J. Urol., 2000, 18:2–9
Yang S X, Song C, Liu Y,et al. The Preparation of Extracellular Matrix for the Replacement of Urethra.Chin. J. Urol., 2003, 24:555–557
Kleinman H K, Philp D, Hoffman M P. Role of the Extracellular Matrix in Morphogenesis.Current Opinion in Biotechnology, 2003, 14:526–532
Sievert K D, Tanagbo E A. Organ-specific Acellular Matrix for Reconstruction of the Urinary Tract.World J. Urol., 2000, 18:19–25
Atala A. Tissue Engineering for the Replacement of Organ Function in the Genitourinary System.Am. J. Trans., 2004, 4 (Suppl. 6):58–73
Wakatsuki T, Elson E L. Reciprocal Interactions between Cells and Extracellular Matrix during Remodeling of Tissue Constructs.Biophys. Chem., 2003, 100:593–605
Author information
Authors and Affiliations
Corresponding author
Additional information
Funded by the Natural Science Foundation of Hubei Province (No. 2003ABA187) and by Hubei Education Bureau (No. 2003X123)
Rights and permissions
About this article
Cite this article
Sixing, Y., Kaiyu, Q., Tianpeng, W. et al. Preparation of urethral extracellular matrix and its biocompatibility. J. Wuhan Univ. Technol.-Mat. Sci. Edit. 20, 4–6 (2005). https://doi.org/10.1007/BF02841268
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02841268