Skip to main content
Log in

The microstructure and gelling mechanism of thermo-responsive chitosan hydrogel system

  • Published:
Journal of Wuhan University of Technology-Mater. Sci. Ed. Aims and scope Submit manuscript

Abstract

Thermo-responsive chitosan hydrogel system (TRCHS) was prepared and its microstructure was investigated by scaning electron microscope (SEM) and mercury intrusion poremaster (MIP). Based on analyzing the data, a special porosity property was reported at the first time. Its gelling mechanism was studied by a group of contrast experiments. Results may provide experimental and theoretical supports for how to apply it on tissue engineering scaffold and how to influence or control its essential properties.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Chenite A, Chaput C, Wang D,et al. Novel Injectable Neutral Solutions of Chitosan form Biodegradable Gels in Situ[J].Biomaterials, 2000, 21(21):2155

    Article  CAS  Google Scholar 

  2. Lee K Y, Ha W S, Park W H. Blood Compatibility and Biodegradability of Partially N-acylated Chitosan Derivatives[J].Biochematerials, 1995, 16(16):1211–6

    Article  CAS  Google Scholar 

  3. Molinaro G, Leroux J C, Damas J,et al. Biocompatibility of Thermosensitive Chitosan-based Hydrogels: An in vivo Experimental Approach to Injectable Biomaterials [J].Biomaterials, 2002, 23(13):2717

    Article  CAS  Google Scholar 

  4. Tomihata K, Ikada Y. In Vitro and in vivo Degradation of Films of Chitin and Its Deacetylated Derivatives [J].Biomaterials, 1997, 18(7):567

    Article  CAS  Google Scholar 

  5. Varum, Kjell M., Myhr,et al. In Vitro Degradation Rates of Partially N-acetylated Chitosans in Human Serum [J].Carbohydrate Research, 1996, 299(2):99

    Article  Google Scholar 

  6. Lahiji A, Sohrabi A, Hungerford DS,et al. Chitosan Supports the Expression of Extracellular Matrix Proteins in Human Osteoblasts and Chondrocytes[J].J. Biomed. Mater. Res., 2000, 51 (4):586–95

    Article  CAS  Google Scholar 

  7. Park Y J, Lee Y M, Lee J Y,et al. Controlled Release of Plateletderived Growth Factor-BB from Chondroitin Sulfate-chitosan Sponge for Guided Bone Regeneration [J].J. Control. Release., 2000, 67(2–3):385–394

    Article  CAS  Google Scholar 

  8. Park Y J, Lee Y M, Park S N,et al. Platelet Derived Growth Factor Releasing Chitosan Sponge for Periodontal Bone Regeneration[J].Biomaterials, 2000, 21(2):53–59

    Article  Google Scholar 

  9. Lee Y M, Park Y J, Lee S J,et al. The Bone Regenerative Effect of Platelet-derived Growth Factor-BB Delivered with a Chitosan/Tricalcium Phosphate Sponge Carrier[J].J. Periodontal., 2000, 71(3):418–424

    Article  CAS  Google Scholar 

  10. Gekko K, Mugishima H, Koga S. Effects of Sugars and Polyols on the Sol-gel Transition of k-carrageenan: Calorimetric Study [J].Int. J. Biol. Macromol., 1987, 9:146

    Article  CAS  Google Scholar 

  11. Yao K D, Liu J. Water in Polymers [J].Polymer Science and Engineering, 1999, 15:5

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Fan Donghui.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Donghui, F., Weiying, Z., Qisheng, G. et al. The microstructure and gelling mechanism of thermo-responsive chitosan hydrogel system. J. Wuhan Univ. Technol.-Mat. Sci. Edit. 21, 109–112 (2006). https://doi.org/10.1007/BF02840853

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02840853

Key words

Navigation