Advertisement

Journal of Zhejiang University-SCIENCE A

, Volume 2, Issue 4, pp 448–452 | Cite as

Changes of oxidative and lipoperoxidative metabolism in patients with acute viral myocarditis

  • Chen Peng
  • Zhou Jun-fu
Life Sciences
  • 23 Downloads

Abstract

Objective: To study the changes of oxidative metabolism and lipoperoxidative metabolism in patients with acute viral myocarditis (AVM), and to research pathological chain reactions of a series of free radicals, and oxidative damage and lipoperoxidative damage in AVM patients' bodies. Methods: A random paired control design was used to investigate 70 cases of AVM patients and 70 cases of healthy adult volunteers (HAV) on the basis of contents of nitric oxide (NO), lipoperoxide (LPO) in plasma, and LPO in red blood cell (RBC) as well as activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in RBC as revealed by spectrophotometric assays. Results: Compared with the average values (AV) of the above biochemical parameters (BP) in the HAV group, the AV of NO in plasma, and LPO in plasma and in RBC in the AVM group were significantly increased (P=0.0001), while the AV of SOD, CAT and GSH-Px in the AVM group were significantly decreased (P=0.0001). Conclusion: The findings in this study suggested that in the AVM patients bodies the metabolism of NO was disturbed, and the pathological chain reactions of a series of free radicals were so severely aggravated, as to cause the oxidative damage and lipoperoxidative damage in the AVM patients' bodies.

Key words

oxidation lipoperoxidation myocarditis metabolism 

Document code

CLC number

R542.21 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Dec G. M., Palacios, I., Yasuda, T. et al. 1990. Antimyosin antibody cardiac imaging: its role in the diagnosis of myocarditis.J Am Coll Cardiol. 16: 97–104.CrossRefGoogle Scholar
  2. Ginsberg, M. D., Fietrich, W. D., 1989. Cerebrovascular diseases. 1st ed. Raven Press, New York, p. 348–374.Google Scholar
  3. Hiraoka, Y., Kishimoto, C., Kurokawa, M. et al., 1992. Effects of polyethylene glycol conjugated superoxide dismutase on coxsackievirus B3 myocarditis in mice.Cardiovasc Res.,26: 956–961.CrossRefGoogle Scholar
  4. Hiraoka, Y., Kishimoto, C., Takada, H. et al., 1993. Role of oxygen derived free radicals in the pathogenesis of coxsackievirus B3 myocarditis in mice.Cardiovasc Res,27: 957–961.CrossRefGoogle Scholar
  5. Hiraoka, Y., Kishimoto, C., Takada, H. et al., 1995. Effects of granulocyte colony-stimulating factor upon coxsackievirus B3 myocarditis in mice.Eur Heart J,16: 1900–1906.Google Scholar
  6. Lang, T. A., Secic, M. 1997. How to report statistics in medicine. Philadelphia: Port City Press, p. 65–80.Google Scholar
  7. Murray, R. K. 2000. Muscle and the cytoskeleton.In: Murray, R. K., Granner D. K., Mayes, P. A. et al., ed. Harper's Biochemistry. 25th ed, McGraw-Hill Press, New York, p. 715–736.Google Scholar
  8. O'Connell, J. B., Renlund, D. G., 1998. Myocarditis and specific cardiomyopathies.In: Hurst's the heart. Alexander R. W., Schlant, R. C., O'Rourke V. F. R. A. et al., ed. 9th ed, McGraw-Hill Press, New York, p. 2089–2107.Google Scholar
  9. Peters, N. S., Poole-Wilson, P. A., 1991a. Myocarditiscontinuing clinical and pathologic confusion.Am Heart J.,121: 942–949.CrossRefGoogle Scholar
  10. Peters, N. S., Poole-Wilson, P. A., 1991b. Myocarditis—a controversial disease.J. R. Soc. Med.,84: 1–9.Google Scholar
  11. Suzuki, H., Matsumori, A., Matoba, Y. et al., 1993. Enhanced expression of superoxide dismutase messenger RNA in viral myocarditis. An SH-dependent reduction of its expression and myocardial injury.J Clin Invest. 91: 2727–2733.CrossRefGoogle Scholar
  12. Wynne, J., Braunwald, E., 1997. The cardiomyopathies and myocarditis.In: Heart disease-A textbook of cardiovascular medicine, Braunwald, E. ed., 5th ed., Hacourt Asia Pte, Ltd, Singapore, p. 1404–1463.Google Scholar
  13. Yang, Y. Z., 1995. The reference criterion of diagnosis about adult acute viral myocarditis.J. Clin Cardiol.,11: 325–326 (in Chinese).Google Scholar
  14. Zhou, J. F., Yan, X. F., Guo, F. Z. et al., 2000a. Effects of cigarette smoking and smoking cessation on plasma constituents and enzyme activities related to oxidative stress.Biomed Environ Sci.,13: 44–55.Google Scholar
  15. Zhou, J. F., Cai, D., Zhu, Y. G. et al., 2000b. A study on relationship of nitric oxide, oxidation, peroxidation, lipoperoxidation with chronic cholecyslitis.World J. Gastroenterology,6: 501–507.Google Scholar

Copyright information

© Zhejiang University Press 2001

Authors and Affiliations

  • Chen Peng
    • 1
  • Zhou Jun-fu
    • 1
  1. 1.The Second Affiliated Hospital, College of MidicineZhejiang UniversityHangzhouChina

Personalised recommendations