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Sequential analysis for comparing the effect of Keyin Decoction with retinoic acid in treating psoriasis

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Abstract

Objective: To compare the effect of Keyin Decoction with retinoic acid in treating psoriasis.Methods: One hundred and six patients were randomly divided by paired grouping into the KYD group and the all-trans retinoic acid (RA) group, 53 in each group with 19 cases belonging to Wind-Heat Syndrome type and 34 to Wind-Dryness type. The Wind-Heat Syndrome type in the KYD group was treated with KYD I (with the action of clearing Heat, removing Dampness, cooling blood and dispelling Wind), and the Wind-Dryness type with KYDII (with the action of nourishing blood, moistening skin and dredging Qi-blood circulation). The RA group was treated with RA. Sequential analysis was adopted to observe the effect. At the same time, the adverse reaction was observed.Results: When the test got to the 44th pair of patients, the scription of result reached the UA line of sequential chart, suggesting that the efficacy of KYD was superior to that of RA. Skin lesion subsidence rate in the KYD group and the RA group was 39.6% and 20.8% respectively with significant difference (P<0.05). And for the patients of progressive phase in the two groups, skin lesion subsidence rate was 57.8% and 21.1% respectively (P< 0.05). No obvious adverse reaction was found in the KYD group.Conclusion: Keyin Decoction had good effect in treating psoriasis.

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References

  1. WANG GC edit. Dermatology. Beijing: Publishing House of People Health, 1994: 140–146.

    Google Scholar 

  2. Fredriksson T, Pettersson U. Severe psoriasis oral therapy with a new retinoid. Dermatologica, 1978; 157: 238 -240.

    Article  PubMed  CAS  Google Scholar 

  3. QIN XW, ZHENG MR, MU XL, et al. Effect of baicalin on chemotaxis of neutrophil induced by leukotriene B4 in patients with psoriasis. Chin J Dermatol 1998; 32(2): 116–117.

    Google Scholar 

  4. ZHENG MR, FANG YM, XIE Y, et al. Report on 45 patients of psoriasis treated by Kangyin No. 3. Clin J Dermatol 1996; 25(2): 91.

    Google Scholar 

  5. LI YL, ZHOU QY, LU G. Effect of combined use of astragalus and retinamidoester on nail fold microcirculation in patients with psoriasis. Chin J Dermatovenereol 1998; 12(6): 345–346.

    Google Scholar 

  6. GAN J, ZHANG XC, LU J, et al. Comparative study on effects of ginkgo, astragalus and their composite prescription on function of macrophage. Hunan J TCM 1998; 14(1): 49.

    Google Scholar 

  7. WANG YN, LIU XM, YANG ZP. Clinical observation on treatment of psoriasis with Keyin decoction. Hebei Medical J 1999; 21(6): 470–471.

    Google Scholar 

  8. WANG YN, LIU XM, LIU WJ, et al. Clinical observation on effect of Keyin decoction on platelet index in patients with psoriasis. Chin Prac J Integr Chin with Modern Med 2000; 13(22): 2160–2161.

    Google Scholar 

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Correspondence to Wang Yan-ning.

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Yan-ning, W., Jun, G. Sequential analysis for comparing the effect of Keyin Decoction with retinoic acid in treating psoriasis. Chin. J. Integr. Med. 9, 108–111 (2003). https://doi.org/10.1007/BF02838560

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