Advertisement

Chinese Journal of Integrative Medicine

, Volume 10, Issue 1, pp 14–18 | Cite as

Effect of Xiongshao Capsule on the function of vascular endothelium of patients with cervical atherosclerosis

  • Xu Feng-qin
  • Li Li-zhi
  • Xu Hao
  • Yao Li-fang
  • Chen Ke-ji
  • Shao Nian-fang
Original Articles

Abstract

Objective:To study the effect of Xiongshao Capsule (XSC), a TCM herb that can promote blood circulation to remove blood stasis, on the endothelial dependent relaxation function, serum nitric oxide (NO), and plasma endothelin-KET-1) of the patients with cervical atherosclerosis.Methods: Forty patients were randomly divided into two groups: XSC group and Probucol group (western medicine control). In addition, 20 healthy people were set as a normal control group. Plasma ET-1, serum NO, the internal diameter of basal brachial artery, endothelial dependent flow mediated dilation (FMD) and non-endothelial dependent nitroglycerin induced dilation (NID) to the trial group before and after therapy and to the healthy control group were determined respectively. Results: Compared to the healthy control group, FMD of patients with atherosclerosis was damaged obviously, the serum NO level decreased, plasma ET-1 increased (P< 0.01), NID also decreased (P<0.05), the internal diameter of basal brachial artery has no obvious difference (P>0.05). After the patients with atherosclerosis were treated with Xiongshao Capsule for 12 weeks, FMD increased evidently, plasma ET-1 decreased, serum NO and the ratio of NO/ET-1 increased, compared with the level before therapy and Probucol group, the difference was significant (P<0.05,P<0.01), NID didn’t change obviously (P>0.05).Conclusion: XSC could regulate vascular activity factor and improve the function of endothelial dependent vascular dilation of patients with atherosclerosis.

Key words

atherosclerosis endothelial vasodilator function Xiongshao Capsule 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Ross R. The pathogensis of atherosclerosis — an update. N Engl J Med 1986;314(8): 488–500.PubMedCrossRefGoogle Scholar
  2. 2.
    Healy B. Endothelial cell dysfunction: An emerging endocrinopathy linked to coronary disease. J Am Coll Cardiol 1990; 16(2): 357–358.PubMedGoogle Scholar
  3. 3.
    Reddy KG, Nair RN, Sheehan HM, et al. Evidence that selective endothelial dysfunction may occur in the absence of angiographic or ultrasound atherosclerosis in patients with risk factors for atherosclerosis. J Am Coll Cardiol 1994;23(4): 833–843.PubMedCrossRefGoogle Scholar
  4. 4.
    Werns SW, Walton JA, Hsia HH, et al. Evidence endothelial dysfunction in angiographically normal coronary arteries of patients with coronary artery disease. Circulation 1989;79(2): 287–291.PubMedGoogle Scholar
  5. 5.
    Xu H, Shi DZ, Chen KJ, et al. Effect of Xiongshao Capsule on vessel remodeling of pig coronary artery after saccule was hurt. Chin J Integr Tradit West Med 2001; 21(8): 591–599.Google Scholar
  6. 6.
    Celermajer Ds, Sorensen KE, Bull Gooch VM, et al. Non-invasive detection of endothelial dysfunction in children and at risk of atherosclerosis. Lancet 1992; 340: 1111–1115.PubMedCrossRefGoogle Scholar
  7. 7.
    Li Liang, Zhao Shuiping, Li Xiangping, et al, Non-invasive detection of endothelial dysfunction in patients with essential hypertension. Int J Cardiol 1997; 16(2): 165–169.Google Scholar
  8. 8.
    Liang RX, Huang LQ, Liu JF, et al. Experimental observation of Chuanxiong and Chishao on reducing blood lipoid of hyperglycemia rats, anti-oxidation and vascular endothelium function. Chin J Exper Trad Med Form 2002;8(1): 43–45.Google Scholar
  9. 9.
    Wang X, Han GQ, Li RZ, et al. Screening and research of modern bio-analysis on common Chinese Medicine. J Beijing Med Univ 1986; 18(1): 31–35.Google Scholar
  10. 10.
    Zhou SC, Zheng ZS. Early examination and treatment to dependent dysfunction of vascular endothelium. South China J Cardiovasc Dis 1998;4(1): 62–64.Google Scholar

Copyright information

© The Chinese Journal of Integrated Traditional and Western Medicine Press 2004

Authors and Affiliations

  • Xu Feng-qin
    • 1
  • Li Li-zhi
    • 1
  • Xu Hao
    • 1
  • Yao Li-fang
    • 1
  • Chen Ke-ji
    • 1
  • Shao Nian-fang
    • 2
  1. 1.Xiyuan HospitalChina Academy of Traditional Chinese Medicine
  2. 2.The Affiliated Hospital to Shandong University of TCMChina

Personalised recommendations