, Volume 10, Issue 1, pp 41–49 | Cite as

The Nobel Prize in Chemistry 2004

‘Ubiquitous’ quality control of life
  • C. S. Karigar
  • K. R. Siddalinga Murthy
General Article


The Nobel Prize in Chemistry for 2004 is shared by Aaron Ciechanover, Avram Hershko and Irwin Rose, who made fundamental discoveries concerning how cells regulate the breakdown of cellular proteins with extreme specificity. The three biochemists discovered ubiquitin-mediated proteolysis, a process where an enzyme system tags unwanted proteins with many molecules of a small protein called ubiquitin and then sends then to the proteasome where they are broken down.


Ubiquitin proteasome protein degradation proteolysis Nobel Prize Chemistry 2004 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Suggested Reading

  1. [1]
    A Ciechanover, The Ubiquitin-Proteasome Proteolytic Pathway,Cell, Vol. 79, pp.13–21, 1994.CrossRefGoogle Scholar
  2. [2]
    B Alberts, A Johnson, J Lewis, M Raff, K. Roberts and P Walter, Molecular biology of the cell,Garland Science, New York, p. 358,2002.Google Scholar
  3. [3]
    www.kva.seGoogle Scholar
  4. [4] Scholar

Copyright information

© Indian Academy of Sciences 2005

Authors and Affiliations

  • C. S. Karigar
    • 1
  • K. R. Siddalinga Murthy
    • 1
  1. 1.Biochemistry Division Department of ChemistryBangalore UniversityBangaloreIndia

Personalised recommendations