Advertisement

The Chinese-German Journal of Clinical Oncology

, Volume 2, Issue 4, pp 243–245 | Cite as

Effect of platelet activation and endothelial cell injury on malignant cancer

  • Sun Dachun
  • Zhang Aihua
  • Li Xiaoliang
  • Wu Hong
  • He Zhiguo
Original Articles

Abstract

Objective: To study the effects of platelet activation and endothelial cell injury on the patients with malignant tumor and their prognoses.Methods: Radioimmunity and ELISA methods were employed to detect the TXB2, GMP-140, vWF, cGMP and FN in 78 cases of malignant tumor and 40 healthy control persons.Results: The levels of TXB2, MP-140 and cGMP were increased in intestinal cancer group, lung cancer group and hepatic cancer group, while FN decreased in intestinal cancer and lung cancer group. cGMP was positively related to TXB2, GMP-140, vWF in malignant tumor group. FN was decreased in the group complicated with infection and the group with metastasis, while the other indexes increased. GMP-140, vWF and cGMP was decreased after operation except for the increasing of FN.Conclusion: Activations of platelet and injury of endothelial cells developed in patients with malignant tumor, and both of them affected the metastasis and prognosis of malignant tumor.

Key words

platelet activation epithelium injury malignant tumor metastasis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Blann AD, Lip GY, Beevers DG,et al. Soluble P-selectin in atherosclerosis: a comparison with endothelial cell and platelet markers. Thromb Haemost, 1997, 77: 1077–1080.Google Scholar
  2. 2.
    Leo R, Pratico D, Iuliano L,et al. Platelet activation by superoxide anion and hydroxyl radicals intrinsically generated by platelets that had undergone anoxia and then reoxygenated. Circulation, 1997, 95: 885–891.CrossRefPubMedGoogle Scholar
  3. 3.
    Jin Rb. Progress of investigation on injury of vascular endothelial cell. Military Medicine Foreign Medical Sciences, 1994, 11: 49–52.Google Scholar
  4. 4.
    Si, LS, Wang YL. Cell adhesive molecule and its role in pathology. Chin J Pathol, 1994, 23: 245–248.Google Scholar
  5. 5.
    Wang MD, Lin DY. Observating on level of cyclic nucleic acid in tumor tissue of oral and maxillofacial region. Chin J Stomatol, 1995, 30: 146–147.Google Scholar
  6. 6.
    Rocha E, Páramo JA, Fernández FJ,et al. Clotting activation and impairment of fibrinolysis in malignancy. Thromb Res, 1989, 54: 699–707.CrossRefPubMedGoogle Scholar
  7. 7.
    Li JZ, He SL, Wang HL. Thrombotic Disease. Beijing: Science Publishing house, 1998. 243–247.Google Scholar

Copyright information

© Springer 2003

Authors and Affiliations

  • Sun Dachun
    • 1
  • Zhang Aihua
    • 1
  • Li Xiaoliang
    • 1
  • Wu Hong
    • 1
  • He Zhiguo
    • 1
  1. 1.Zhuhai People’s HospitalThe Third Affiliated Hospital of Jinan UniversityZhuhaiChina

Personalised recommendations