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Basic fibroblast growth factor and fibroblast growth factor receptor-1 in human meningiomas

  • Yi Wei
  • Chen Jian
  • Filimon H. Golwa
  • Xue Delin
Article

Summary

The expression of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-1 (FGFR-1) in human meningiomas and the relationships between their expression and the tumors' histological features and angiogenesis were investigated by means of immunohistochemical technique. The expression of bFGF and FGFR-1 was detected by antibody of bFGF or FGFR-1. the tumors' angiogenesis was evaluated by microvascular density (MVD) and, which was observed by use of CD34-antibody immunohistochemically. The results showed that there were varied degrees of the expression of bFGF and FGFR-1 proteins in meningiomas. The expression was correlated with the tumors' histological characters and angiogenesis. It was concluded that bFGF and FGFR-1 might play important roles in meningiomas' angiogenesis and proliferation. The expression positive rate of bFGF and FGFR-1 may provide an indication of evaluating the histological and malignant degree of the tumor.

Key words

meningiomas basic fibroblast growth factor fibroblast growth factor receptor-1 microvascular density immunohistochemistry 

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Copyright information

© Springer 2005

Authors and Affiliations

  • Yi Wei
    • 1
  • Chen Jian
    • 1
  • Filimon H. Golwa
    • 1
  • Xue Delin
    • 1
  1. 1.Department of Neurosurgery, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

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