Synthesis, structure and antitumor activities of [Ni(dien)2][Ni(CN)4] complex

  • Li Tao
  • Liang Feng
  • Zhang Shi-wei
  • Wu Cheng-tai


Ni(II)-dien complex was prepared and characterized by X-ray diffraction. The crystal belongs to triclinic system, space group P-1, with crystallographic parametersa=0.888 13(18) nm,b=0.890 10(18) nm,c=1. 591 8(3) nm, α=77.71(3)°, β=89.12(3)°, γ=61.24(3)°,Z=2. The two dien molecules coordinate to the central Ni atom, the six nitrogen atoms form a distorted octahedron. Preliminary pharmacological tests showed this complex had antitumor activity against HepG2 and HL-60 cell linesin vitro.

Key words

polyamines Ni(II) complex crystal structure antitumor activity 

CLC number

O 626 


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Copyright information

© Springer 2004

Authors and Affiliations

  • Li Tao
    • 1
  • Liang Feng
    • 2
  • Zhang Shi-wei
    • 3
  • Wu Cheng-tai
    • 2
  1. 1.Department of Ophthalmology, The Affiliated Tongji HospitalTongji Medical College of Huazhong University of Science and TechnologyWuhan, HubeiChina
  2. 2.College of Chemistry and Molecular SciencesWuhan UniversityWuhan, HubeiChina
  3. 3.State Key Laboratory for Structural Chemistry of Stable and Unstable SpeciesPeking UniversityBeijingChina

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