Advertisement

Synthesis, structure and antitumor activities of [Ni(dien)2][Ni(CN)4] complex

  • Li Tao
  • Liang Feng
  • Zhang Shi-wei
  • Wu Cheng-tai
Article

Abstract

Ni(II)-dien complex was prepared and characterized by X-ray diffraction. The crystal belongs to triclinic system, space group P-1, with crystallographic parametersa=0.888 13(18) nm,b=0.890 10(18) nm,c=1. 591 8(3) nm, α=77.71(3)°, β=89.12(3)°, γ=61.24(3)°,Z=2. The two dien molecules coordinate to the central Ni atom, the six nitrogen atoms form a distorted octahedron. Preliminary pharmacological tests showed this complex had antitumor activity against HepG2 and HL-60 cell linesin vitro.

Key words

polyamines Ni(II) complex crystal structure antitumor activity 

CLC number

O 626 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. [1]
    Thomas T, Thomas T J. Polyamines in Cell Growth and Cell Death: Molecular Mechanisms and Therapeutic Applications.Cell Mol Life Sci, 2001,58:244–258.CrossRefGoogle Scholar
  2. [2]
    Shah N, Antony T, Haddad S, eitet al. Antitumor Effects of Bis(ethyl)Polyamines Analogs on Mammary Tumor Development in FVB/NTgN (MMTVneu) Transgenic Mice.Cancer Lett, 1999,146:15–23.CrossRefGoogle Scholar
  3. [3]
    Fraser A V, Woster P M, Wallace H M. Induction of Apoptosis in Human Leukaemic Cells by IPENSpm, a Novel Polyamine Analogue and Anti-Metabolite.Biochem J, 2002,367:307–312.CrossRefGoogle Scholar
  4. [4]
    Kingsnorth A N, Wallace H M, Bundred N J,et al. Polyamines in Breast Cancer.Br J Surgery, 1984,71:352–356.CrossRefGoogle Scholar
  5. [5]
    Kingsnorth A N, Lumsden A B, Wallace H M. Polyamines in Colorectal Cancer.Br J Surgery, 1984,71:791–794CrossRefGoogle Scholar
  6. [6]
    Yoshinari K, Yamazaki K, Komiyama M. Oligoamines as Simple and Efficient Catalysts for RNA Hydrolysis.J Am Chem Soc, 1991,113:5899–5901.CrossRefGoogle Scholar
  7. [7]
    Komiyama M, Yoshinari K. Kinetic Analysis of Diamine-Catalyzed RNA Hydrolysis.J Org Chem, 1997,62:2155–2160.CrossRefGoogle Scholar
  8. [8]
    Carotti S, Guerri A, Mazzei T,et al. Gold (III) Compounds as Potential Antitumor Agents: Cytotoxicity and DNA Binding Properties of Some Selected Polyamine-Gold (III) Complexes.Inorg Chim Acta, 1998,281:90–94.CrossRefGoogle Scholar
  9. [9]
    Messori L, Abbate F, Marcon G,et al. Gold(III) Complexes as Potential Antitumor Agents: Solution Chemistry and Cytotoxic Properties of Some Selected Gold(III) Compounds.J Med Chem, 2000,43:3541–3548.CrossRefGoogle Scholar
  10. [10]
    Wu M H, Cheng G P, He Y B,et al. A Practical Synthesis of Hydroxyl-N-Tosylcyclams via Cyclization of 1,3-Dichloro-2-Propanol with Disodium Di (poly)-N-Tosylamides.Syn Commun, 1995,25:1427–1431.CrossRefGoogle Scholar
  11. [11]
    Xue G P, Liu Y, Wu C T. A Practical Synthesis of Novel Hydroxyl-Substituted Macrocyclic Tri-, Tetra- and Hexa-Amines.Chin J Chem, 1998,16:538–541.Google Scholar
  12. [12]
    Liang F, Wu X, Zhang S,et al. A Convenient Synthesis and Crystal Structure of Octahydro-Pyrazino[1, 2-a] Pyrazine.Syn Commun, 2004,34:827–833.Google Scholar
  13. [13]
    Liang F, Wu C T, Li Z Y,et al. Synthesis and Antitumor Activities of Hydroxyl-Substituted Macrocyclic Polyamines and Their Complexes.Chemical Journal on Internet, 2003,5:6.Google Scholar
  14. [14]
    Liang F, Wu C T, Lin H,et al. Copper Complex of Hydroxyl-Substituted Triazamacrocyclic Ligand and Its Antitumor Activity.Bioorg Med Chem Lett, 2003,13:2469–2472.CrossRefGoogle Scholar
  15. [15]
    Liang Feng, Wei Jun, Li Zhao-yang,et al. Hydroxyl Macrocyclic Polyamines Coordination Systems Interaction with DNA and Their Antitumor Activitiesin vitro.Chem J Chin Univ, 2004,25:1190–1193 (Ch).Google Scholar
  16. [16]
    Liang F, Wang P, Zhou X,et al. Nickle(II) and Cobalt(II) Complexes of Hydroxyl-Substituted Triazamacrocyclic Ligand as Potential Antitumor Agents.Bioorg Med Chem Lett, 2004,14(7):841–844.Google Scholar

Copyright information

© Springer 2004

Authors and Affiliations

  • Li Tao
    • 1
  • Liang Feng
    • 2
  • Zhang Shi-wei
    • 3
  • Wu Cheng-tai
    • 2
  1. 1.Department of Ophthalmology, The Affiliated Tongji HospitalTongji Medical College of Huazhong University of Science and TechnologyWuhan, HubeiChina
  2. 2.College of Chemistry and Molecular SciencesWuhan UniversityWuhan, HubeiChina
  3. 3.State Key Laboratory for Structural Chemistry of Stable and Unstable SpeciesPeking UniversityBeijingChina

Personalised recommendations