Bis(7)-tacrine ameliorates cognitive impairment caused by cerebral hypoperfusion in rats

  • Peng Fang-fang
  • Zhang Bai-fang
  • Zhang Jiang-zhou
  • Wu Dong-cheng


The effects ofbis(7)-tacrine, a novel acetylcholinesterase inhibitor, on cognitive impairment and neuronal degeneration induced by permanent ligation of bilateral common carotid arteries (2VO) were investigated using the Morris water maze in rats. Once daily oral administration ofbis(7)-tacrine (0.025, 0.05 and 0.1 mg·kg−1) was started 14 days after 2VO operation. Over a three-week treatmentbis(7)-tacrine effectively reversed 2VO-induced spatial memory deficits in a dose-dependent fashion. Furthermore, histological observation showedbis(7)-tacrine decreased the neuropathological changes in the 2VO rats brain. These results suggest thatbis(7)-tacrine has therapeutic potential for the treatment of dementia caused by chronic cerebral hypoperfusion.

Key words

bis(7)-tacrine acetylcholinesterase inhibitor permanent bilateral occlusion of common carotid arteries vascular dementia 

CLC number

R 965 R 749.16 


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Copyright information

© Springer 2002

Authors and Affiliations

  • Peng Fang-fang
    • 1
  • Zhang Bai-fang
    • 1
  • Zhang Jiang-zhou
    • 1
  • Wu Dong-cheng
    • 1
  1. 1.Department of Biochemistry, School of MedicineWuhan UniversityWuhan, HubeiChina

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