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Bis(7)-tacrine ameliorates cognitive impairment caused by cerebral hypoperfusion in rats

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Wuhan University Journal of Natural Sciences

Abstract

The effects ofbis(7)-tacrine, a novel acetylcholinesterase inhibitor, on cognitive impairment and neuronal degeneration induced by permanent ligation of bilateral common carotid arteries (2VO) were investigated using the Morris water maze in rats. Once daily oral administration ofbis(7)-tacrine (0.025, 0.05 and 0.1 mg·kg−1) was started 14 days after 2VO operation. Over a three-week treatmentbis(7)-tacrine effectively reversed 2VO-induced spatial memory deficits in a dose-dependent fashion. Furthermore, histological observation showedbis(7)-tacrine decreased the neuropathological changes in the 2VO rats brain. These results suggest thatbis(7)-tacrine has therapeutic potential for the treatment of dementia caused by chronic cerebral hypoperfusion.

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Authors and Affiliations

  1. Department of Biochemistry, School of Medicine, Wuhan University, 430071, Wuhan, Hubei, China

    Peng Fang-fang, Zhang Bai-fang, Zhang Jiang-zhou & Wu Dong-cheng

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  1. Peng Fang-fang
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  2. Zhang Bai-fang
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  3. Zhang Jiang-zhou
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  4. Wu Dong-cheng
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Additional information

Foundation item: Supported by the National Natural Science Foundation of China (No: 30170335)

Biography: Peng Feng-fang(1966-), female Master, research direction: Alzheimer's disease and ischemia

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Fang-fang, P., Bai-fang, Z., Jiang-zhou, Z. et al. Bis(7)-tacrine ameliorates cognitive impairment caused by cerebral hypoperfusion in rats. Wuhan Univ. J. Nat. Sci. 7, 248–252 (2002). https://doi.org/10.1007/BF02830328

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  • DOI: https://doi.org/10.1007/BF02830328

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