Wuhan University Journal of Natural Sciences

, Volume 6, Issue 3, pp 742–746 | Cite as

The study on BCR/ABL fusion gene in adult acute lymphoblastic leukemia

  • Li Hui-yu
  • Zuo Guo-Lin
  • Zuo Ping


In order to assess the significance of BCR/ABC fusion gene in adult acute lymphoblastic Leukemia (ALL), 28 patients who were diagnosed as ALL were enrolled to detect BCR/ABC gene using nested-RT-PCR. The results showed that 9 cases (31.25%) were BCR/ABL positive, and expressed P210 subtype. Among them 7 cases were B-ALL, and one was T-ALL. The diagnosis was proved by monoclonal antibodies recognition by indirect immunofluorescence. Adult patients with BCR/ABL positive ALL were significantly older (p<0.01) and had higher WBC count (p<0.01) as compared with BCR/ABL-negative patients. There was no significant difference in sex, hemoglobin and splenomegaly between two group (p>0.05). The induction failure rate was high in BCR/ABL positive patients and those who achieved complete remission usually relapsed earlier. In conclusion, adult ALL patients with BCR/ABL-positive have poorer prognosis.

Key words

BCR/ABL gene acute lymphoblastic leukemia nested-RT-PCR 

CLC number

R 733.71 


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Copyright information

© Springer 2001

Authors and Affiliations

  • Li Hui-yu
    • 1
    • 2
  • Zuo Guo-Lin
    • 1
  • Zuo Ping
    • 2
  1. 1.College of Life ScienceWuhan UniversityWuhanChina
  2. 2.Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

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