Advertisement

The Indian Journal of Pediatrics

, Volume 42, Issue 11, pp 326–328 | Cite as

Effects of dexamethasone on viscera and post natal development of neonatal rats

  • Kirt Kumar Jain
Article
  • 14 Downloads

Summary and Conclusion

Neonatal albino rats injected with dexamethasone, sodium phosphate were studied at regular intervals by clinical, radiological and histological methods.

Growth of the soft and skeletal tissues of these animals was retarded, the skin was wrinkled and the appearance of the fur was delayed. The thymus was atrophied and the other internal organs were severely depleted of lymphocytes.

The effects are thought to be dose related and the drug action may occur at the cellular level, perhaps on nucleoproteins, which are responsible for the energy generating and division processes of the cells.

Keywords

Dexamethasone Cortisone Antibody Produce Cell Estradiol Benzoate Cortisone Acetate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Fein, A., Ornoy, A. and Nebel, L. (1974). Effects of cortisone on the foetal and neonatal thymolymphatic organs in rats.J. Anat. 117, 223.PubMedGoogle Scholar
  2. Gleen, E.M. (1964). Proc. First Int. Cong. Hormonal Steroids, 1, 319. Cited by Krantz, J.C. Jr. and Carr, C.J. (1969). The Pharmacologic Principles of Medical Practice. p. 667,Williams and Wilkins Baltimore.Google Scholar
  3. Grossfeld, H. and Ragan, C. (1954). Action of hydrocortisone on Cells in tissue culture.Proc. Soc. Exp. Biol. Med. 86, 63.PubMedGoogle Scholar
  4. Ioachim, H.I. (1971). The cortisone induced wasting disease of newborn rats, histopathological and autoradiographic studies.J. Path. 104, 201.PubMedCrossRefGoogle Scholar
  5. Lee, R.E. and Domm, L.V. (1967). A histological and histochemical study on the effects of adrenal cortical steroids in the foetal and neonatal rat thymus,Anat. Rec. 157, 105.PubMedCrossRefGoogle Scholar
  6. Miller, J.P. (1962). Effect of neonatal thymectomy on the immunological responsiveness of the mouse.Proc. Roy. Soc. B. 156, 415.CrossRefGoogle Scholar
  7. Petranyi, G.Y. Jr., Benczur, M. and Alfoldy, P. (1971). The effect of single large dose hydrocortisone treatment on IgM and IgG antibody production: Morphological distribution of antibody producing cells and immunological memory.Immunology,21, 151.PubMedGoogle Scholar
  8. Schapiro, S. (1965). Neonatal cortisol administration: Effect on growth. The adrenal gland and pituitary adrenal response to stress.Proc Soc. Exp. Biol. Med. 120, 771.Google Scholar
  9. Safriel, O.J., Ornoy, A., Nebel, L. and Finkelstein, M. (1972). The effect of cortisone acetate and estradiol benzoate given to pregnant rats on the structural differentiation of the adrenal cortex and the ovary in their offspring.Adv. Exp. Med. Biol. 27, 243.PubMedGoogle Scholar
  10. Winick, M. and Coscia, A. (1963). Cortisone induced growth failure in neonatal rats.Pediat. Res. 2, 451.Google Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 1975

Authors and Affiliations

  • Kirt Kumar Jain
    • 1
  1. 1.Department of AnatomyMaulana Azad Medical College and Associated Irwin and G.B. Pant HospitalsNew Delhi-1

Personalised recommendations