Journal of Clinical Monitoring

, Volume 6, Issue 2, pp 99–106 | Cite as

Commercial double-indicator-dilution densitometer using heavy water: Evaluation in oleic-acid pulmonary edema

  • Lars G. Leksell
  • Mark S. Schreiner
  • Angelina Sylvestro
  • Gordon R. Neufeld
Original Articles


We evaluated a commercially available, double-indicator-dilution densitometric system for the estimation of pulmonary extravascular water volume in oleic acid-induced pulmonary edema. Indocyanine green and heavy water were used as the nondiffusible and diffusible tracers, respectively. Pulmonary extravascular water volume, measured with this system, was 67% of the gravimetric value (r = 0.91), which was consistent with values obtained from the radioisotope methods. The measured volume was not influenced by changes in cardiac index over a range of 1 to 4 L · min · m2. This system is less invasive than the thermal-dye technique and has potential for repeated clinical measurements of pulmonary extravascular lung water and cardiac output.

Key words

Lung: volume, extravascular water: edema Measurement techniques: densitometry 


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Copyright information

© Little, Brown and Company 1990

Authors and Affiliations

  • Lars G. Leksell
    • 1
  • Mark S. Schreiner
    • 2
  • Angelina Sylvestro
    • 1
  • Gordon R. Neufeld
    • 1
  1. 1.Department ot AnesthesiaThe University of Pennsylvania School ot MedicinePhiladelphia
  2. 2.The Childrens Hospital ot PhiladelphiaPhiladelphia

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