Clinical Reviews in Allergy & Immunology

, Volume 15, Issue 1, pp 53–63 | Cite as

Antiendothelial cell antibodies (AECA) in systemic lupus erythematosus (SLE)

  • David D′Cruz
  • Munther Khamashta
  • Graham Hughes
Autoimmune Vasculitis


There is now overwhelming evidence that AECAs exist and are commonly found in the sera of patients with SLE and other autoimmune connective tissue dieases. In many of these diseases, the antibodies mirror disease activity; in SLE, they are associated with clinical manifestations such as nephritis, vasculitis, and thrombosis. The main challenges for the future include the practical aspects of standardizing a technique for measuring AECAs and assessing the potential role for these antibodies in pathogenicity.


Systemic Lupus Erythematosus Vasculitis Systemic Lupus Erythematosus Patient Lupus Nephritis Clinical Review 


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Copyright information

© Humana Press Inc 1997

Authors and Affiliations

  • David D′Cruz
    • 1
    • 2
  • Munther Khamashta
    • 1
    • 2
  • Graham Hughes
    • 1
    • 2
  1. 1.Department of RheumatologyRoyal London HospitalLondonUK
  2. 2.The Lupus Arthritis Research Unit, The Rayne InstituteSt Thomas′ HospitalLondonUK

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