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Possible association of HLA-DRB1 gene with the autoantibody against myocardial mitochondria ADP/ATP carrier in dilated cardiomyopathy

  • Wang Qiufen
  • Liao Yuhua
  • Gong Feili
  • Mao Huanyuan
  • Zhang Jinzhi
Article

Summary

To probe the genetic background and immunopathogenesis of dilated cardiomyopathy (DCM) 77 patients with DCM, HLA-DRB1 gene polymorphism were analyzed by using the polymerase chain reaction/sequence specific primer (PCR/SSP) technique and autoantibody against myocardial mitochondria ADP/ATP carrier were examined by using the Immunoblot analysis. The frequency of HLA-DRB1*0901 allele was significantly higher in DCM patients in which autoantibody against ADP/ATP carrier of myocardial mitochondria is positive in contrast with those in which the autoantibody is negative (25.46% vs 3.45%,P<0.05), the relative risk (RR) being 9.56. The other frequencies of HLA-DRB1 alleles have no significant difference in the antibody positive group and negative group. It is possible that a subset of DCM patients may exist in which autoimmunity is associated with genetic factors.

Key words

dilated cardiomyopathy HLA ADP/ATP carrier 

References

  1. 1.
    Schmidt M A, Mickels V V, Edwards W Det al. Familial dilated cardiomyopathy. Am J Med Genet, 1988, 31: 135.PubMedCrossRefGoogle Scholar
  2. 2.
    Michels VV, Moll PP, Miller FAet al. The frequency of familial dilated cardiomyopathy in a series of patients with idiopathic dilated cardiomyopathy. N Engl J Med, 1992, 326:77PubMedCrossRefGoogle Scholar
  3. 3.
    Limas C, Limas CJ, Boudoulas Het al. HLA-DQA1 and—DQB1 gene haplotypes in familial cardiomyopathy. Am J Cardiol, 1994, 74:510PubMedCrossRefGoogle Scholar
  4. 4.
    Osa A, Almenar L, Palencia Met al. Antigens of the major histocompatibility system in ischemic heart disease and idiopathic dilated cardiomyopathy. Clin Cardiol, 1999, 22:292PubMedGoogle Scholar
  5. 5.
    Limas C J, Limas C, Kubo S Het al. Anti-Beta-Receptor antibodies in human dilated cardiomyopathy and correlation with HLA-DR antigens. Am J Cardiol, 1990, 65:483PubMedCrossRefGoogle Scholar
  6. 6.
    Carlquist J F, Monlove R L, Murray M Bet al. HLA Class II (DR and DQ) antigen associations in idiopathic dilated cardiomyopathy. Circulation, 1991, 83: 515PubMedGoogle Scholar
  7. 7.
    Arbustini E, Gavazzi A, Pozzi Ret al. The morphologic spectrum of dilated cardiomyopathy and it's relation to immune response genes. Am J Cardiolo, 1989, 64:991CrossRefGoogle Scholar
  8. 8.
    Limas C J, Limas C, Goldenberg I Fet al. Possible involvement of the HLA-DQB1 gene in susceptibility and resistance to human dilated cardiomyopathy. Am Heart J, 1995, 129:1141PubMedCrossRefGoogle Scholar
  9. 9.
    Liao Y-H. Functional analysis of autoantibodies against ADP/ATP carrier from dilated cardiomyopathy. International Journal of cardiology, 1996, 54:165CrossRefGoogle Scholar
  10. 10.
    Bodmer L G, Marsh S G E, Albert E Det al. Nomenclature for factors of the HLA system. Tissue Antigens, 1994, 44:1PubMedGoogle Scholar
  11. 11.
    Brandenburg R O, Chazov E, Cherian Get al. Report of the WHO/ISFC task force on the definition and classification of cardiomyopathies. Br Heart J, 1980, 44: 672CrossRefGoogle Scholar
  12. 12.
    Olerup O, Zetterquist H. HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours: An alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantations. Tissue Antigens, 1992, 39: 225PubMedCrossRefGoogle Scholar
  13. 13.
    Liao Y H, Tu Y S, Li S Let al. A study of the autoantibody against an ADP/ATP carrier of myocardial mitochondria in dilated cardiomyopathy. Chinese J Cardiol, 1994, 22:43Google Scholar
  14. 14.
    Caforio A L, Goldman J H, Haven A Jet al. Evidence for autoimmunity to myosin and other heart-specific autoantigens in patients with dilated cardiomyopathy and their relatives. Int J cardiol, 1996, 54:157CrossRefGoogle Scholar

Copyright information

© Springer 2002

Authors and Affiliations

  • Wang Qiufen
    • 1
  • Liao Yuhua
    • 1
  • Gong Feili
    • 2
  • Mao Huanyuan
    • 1
  • Zhang Jinzhi
    • 1
  1. 1.Cardiology DepartmentInstitute of Cardiovascular Disease Tongji Medical UniversityWuhan
  2. 2.Department of Immunology Tongji Medical UniversityWuhan

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