Possible association of HLA-DRB1 gene with the autoantibody against myocardial mitochondria ADP/ATP carrier in dilated cardiomyopathy

  • Wang Qiufen
  • Liao Yuhua
  • Gong Feili
  • Mao Huanyuan
  • Zhang Jinzhi


To probe the genetic background and immunopathogenesis of dilated cardiomyopathy (DCM) 77 patients with DCM, HLA-DRB1 gene polymorphism were analyzed by using the polymerase chain reaction/sequence specific primer (PCR/SSP) technique and autoantibody against myocardial mitochondria ADP/ATP carrier were examined by using the Immunoblot analysis. The frequency of HLA-DRB1*0901 allele was significantly higher in DCM patients in which autoantibody against ADP/ATP carrier of myocardial mitochondria is positive in contrast with those in which the autoantibody is negative (25.46% vs 3.45%,P<0.05), the relative risk (RR) being 9.56. The other frequencies of HLA-DRB1 alleles have no significant difference in the antibody positive group and negative group. It is possible that a subset of DCM patients may exist in which autoimmunity is associated with genetic factors.

Key words

dilated cardiomyopathy HLA ADP/ATP carrier 


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Copyright information

© Springer 2002

Authors and Affiliations

  • Wang Qiufen
    • 1
  • Liao Yuhua
    • 1
  • Gong Feili
    • 2
  • Mao Huanyuan
    • 1
  • Zhang Jinzhi
    • 1
  1. 1.Cardiology DepartmentInstitute of Cardiovascular Disease Tongji Medical UniversityWuhan
  2. 2.Department of Immunology Tongji Medical UniversityWuhan

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