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The effect of nitric oxide/endothelins system on the hepatic ischemia/reperfusion injury

  • Lü Ping
  • Chen Daoda
  • Tian Yuan
  • Zhang Jinghui
  • Wu Yihua
Article

Summary

The relationship between the hepatic ischemia/reperfusion (I/R) injury and the balance of nitric oxide/endothelins (NO/ET) was studied. The changes of the ratio of NO/ET and the hepatic injury were observed in a rat hepatic I/R model pretreated with several tool drugs. In the acute phase of hepatic I/R injury, the ratio of plasma NO/ET was reduced from 1.58±0.20 to 0.29±0.05 (P<0.01) and the hepatic damage deteriorated. NO donor L-Arg and ET receptor antagonist TAK-044 could alleviate the hepatic I/R injury to some degree, whereas NO synthase inhibitor L-NAME aggravated the damage. It was concluded that the hepatic I/R injury might be related with the disturbance of the NO/ET balance. Regulation of this balance might have an effect on the I/R injury.

Key words

hepatic ischemia/reperfusion nitric oxide endothelins 

References

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    Shimamura T, Zhu Y, Zhang Set al. Protective role of nitric oxide in ischemia and reperfusion injury of the liver. J Am Coll Surg, 1999, 188:43PubMedCrossRefGoogle Scholar
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    Pannen B H J, Adili F A, Bauer Met al. Role of endothelins and nitric oxide in hepatic reperfusion injury in the rat. Hepatology, 1998, 27:755PubMedCrossRefGoogle Scholar
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    Dhar D K, Yamanoi A, Ohmori Het al. Modulation of endothelin and nitric oxide: a rational approach to improve canine hepatic microcirculation. Hepatology, 1998, 28:782PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2002

Authors and Affiliations

  • Lü Ping
    • 1
  • Chen Daoda
    • 1
  • Tian Yuan
    • 1
  • Zhang Jinghui
    • 1
  • Wu Yihua
    • 1
  1. 1.Department of General Surgery, Xiehe Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan

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