Association of HLA-DRB1, DQB1 alleles with chronic urticaria
- 32 Downloads
In order to investigate the association of genotypes of HLA-DRB1 and HLA-DQB1 alleles with the genetic susceptibility of chronic urticaria (CU), genotypes of HLA-DRB1 and HLA-DQB1 genes were detected by polymerase chain reactions with sequence-specific primers (PCR-SSP) in 42 patients with CU (19 men and 23 women, mean age 30.67±12.45 y old as well as 193 racially matched healthy persons in ethnic Han from Hubei provinece. Gene frequencies of HLA-DRB1* 12. * 0901 (RR=3.11, χ2=7.579,P=0.006; RR=2.47, χ2=5.684,P=0.017) were significantly increased in CU patients as compared with that in healthy people. Gene frequencies of HLA-DQB1 * 05 (RR=0.26, χ2=6.683,P=0.01) were significantly decreased in CU patients. It was suggested that CU was found strongly associated with HLA-DRB1 * 12, * 0901 and HLA-DQB1 * 05, the former might be the genetic markers for susceptibility to CU, but the latter might play a resistive role.
Key wordsurticaria, chronic genes, MHC class II polymerase chain reaction-sequence specific primer
Unable to display preview. Download preview PDF.
- 13.Cavan D A, Penny M A, Jacobs K Het al. The HLA association with Graves disease is sex-specific in Hong Kong Chinese subjects. Clin Endocrinol, 1994, 40: 63Google Scholar
- 17.Abbas A K, Lichtman A H, Pober J S. eds. Cellular and Molecular Immunology. Philadelphia: W. B. Saunders Company, 1997. 341–61Google Scholar