Association of HLA-DRB1, DQB1 alleles with chronic urticaria

  • Chen Jing
  • Tan Zhijian
  • Li Liawen
  • Xiong Ping


In order to investigate the association of genotypes of HLA-DRB1 and HLA-DQB1 alleles with the genetic susceptibility of chronic urticaria (CU), genotypes of HLA-DRB1 and HLA-DQB1 genes were detected by polymerase chain reactions with sequence-specific primers (PCR-SSP) in 42 patients with CU (19 men and 23 women, mean age 30.67±12.45 y old as well as 193 racially matched healthy persons in ethnic Han from Hubei provinece. Gene frequencies of HLA-DRB1* 12. * 0901 (RR=3.11, χ2=7.579,P=0.006; RR=2.47, χ2=5.684,P=0.017) were significantly increased in CU patients as compared with that in healthy people. Gene frequencies of HLA-DQB1 * 05 (RR=0.26, χ2=6.683,P=0.01) were significantly decreased in CU patients. It was suggested that CU was found strongly associated with HLA-DRB1 * 12, * 0901 and HLA-DQB1 * 05, the former might be the genetic markers for susceptibility to CU, but the latter might play a resistive role.

Key words

urticaria, chronic genes, MHC class II polymerase chain reaction-sequence specific primer 


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Copyright information

© Springer 2005

Authors and Affiliations

  • Chen Jing
    • 1
  • Tan Zhijian
    • 1
  • Li Liawen
    • 1
  • Xiong Ping
    • 1
  1. 1.Department of Dermatology, Union Hospital, Tongji Medical CollegeHuangzhong University of Science and TechnologyWuhanChina

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