A possible association of staphylococcus enterotoxin B-induced asthma and sinusitis

  • Liu Tao
  • Kong Weijia
  • Yang Pingchang
  • Wang Binquan


In order to gain insight into a possible association between chronic sinusitis and asthma, 85 patients with sinusitis and asthma underwent functional endoscopic sinus surgical treatment and serum antibodies and cytokines were measured. The results showed that 51 out of 85 patients with high serum anti-Staphylococcus enterotoxin B (SEB) antibody before treatment obtained satisfactory results for both sinusitis and asthma. The high level of Th2 cytokine IL-4 was down regulated to the levels of normal controls after sinus surgery. Thirty-four out of 85 patients did not show high serum anti-SEB antibody before sinus surgery and did not show much improvement, in their asthmatic symptoms although sinusitis symptoms were resolved by sinus surgery. It was concluded that bacterial superantigen SEB (in the sinuses) might play a crucial role in the pathogenesis of lower airway hypersensitivity.

Key words

asthma sinusitis superantigen Staphylococcus aureus endoscopic sinus surgery IL-1 IFN γ 


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Copyright information

© Springer 2006

Authors and Affiliations

  • Liu Tao
    • 1
    • 2
  • Kong Weijia
    • 1
  • Yang Pingchang
    • 2
  • Wang Binquan
    • 2
  1. 1.Department of Otorhinolaryngology, Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  2. 2.Department of Otolaryngology, The First Affiliated HospitalShanxi Medical UniversityTaiyuanChina

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