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Folia Microbiologica

, Volume 44, Issue 6, pp 721–725 | Cite as

Interrelation of lymphocyte subpopulations in peripheral blood under cervical papillomavirus infection

  • M. Ya. Spivak
  • V. P. Lakatosh
  • L. M. Lazarenko
  • L. M. Lyanenko
  • M. V. Azarskova
  • O. M. Mikhailenko
  • L'. Tkáčiková
  • A. M. Boroda
Article

Abstract

T(CD3+)-, B(CD19+)-lymphocytes and their subsets (CD4+, CD8+, CD3+, DR+, CD3 DR+) in peripheral blood of patients with CIN I, CIN II, CIN III and cancerin situ associated with HPV infection were evaluated. In peripheral blood of women with CIN II, CIN III and cancerin situ the number of T-lymphocytes which expressed CD3+ DR+ antigen decreased. In patients with CIN I, CIN III and cancerin situ the level of the CD4+ cells decreased; the level of the CD8+ cells increased. These patients had a lower CD4/CD8 ratio, the number of B cells being standard. The results may have important implications in the prognosis and immunotherapy of HPV infection.

Keywords

Cervical Cancer Human Leukocyte Antigen Mixed Infection Cervical Intraepithelial Neoplasia Lymphocyte Subpopulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bartholomew J.S., Stacey S.N., Coles B.: Identification of a naturally processed HLA A0201-restricted viral peptide from cell expressing human papillomavirus type 16 E6 oncoprotein.Eur. J. Immunol.24, 3175–3179 (1994).PubMedCrossRefGoogle Scholar
  2. Bosch F.E., Manoz M.M., Munoz N.: Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) Study Group.J. Nat. Cancer Inst.87, 796–802 (1995).PubMedCrossRefGoogle Scholar
  3. Boyum A.: Separation of leukocytes from blood and bone marrow.Scand. J. Clin. Lab. Invest.21, 28–33 (1968).Google Scholar
  4. Chardonnet Y., Bejuithivolet F., Viac J.: Squamous epithelia and human papillomavirus infections.Pathol. Biol.40, 247–256 (1992).PubMedGoogle Scholar
  5. Clerici M., Stocks N.I., Zajac R.A.: Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients.J. Clin. Invest.84, 1892–1899 (1989).PubMedCrossRefGoogle Scholar
  6. Clerici M., Merola M., Ferrario E.: Cytokine production patterns in cervical intraepithelial neoplasia: association with human papillomavirus infection limited to the cervix or involving other sites of the lower genital tract.J. Nat. Cancer Inst.89, 245–250 (1997).PubMedCrossRefGoogle Scholar
  7. Flander A.N., Adams M., Evans A.S.: Immunocompetent for immunotherapy—a study of the immunocompetence of cervical-cancer patients.Internat. J. Gynecol. Cancer5, 438–442 (1995).CrossRefGoogle Scholar
  8. Koutsky L.A., Holmes K.K., Critchlow C.W., Stevens C.E., Paavonen J., Beckmann A.M.: A control study of the risk of cervical intraepithelial neoplasia grade 2 or 3 in relation to papillomavirus infection.New Engl. J. Med.327, 1272–1278 (1992).PubMedCrossRefGoogle Scholar
  9. Lakatosh V.P., Lazarenko L.N., Spivak N.Ya., Lyanenko L.A.: Immune response under HPV-infection and diseases of female genital organs associated with it.Likars'ka Sprava (Kiev)7, 25–36 (1998).Google Scholar
  10. Lakatosh V.P.: Cryosurgical treatment of the benign processes of the cervix uteri associated with papillomavirus infection.Bull. Vinnytsia State Med. Univ.1, 96–97 (1999).Google Scholar
  11. Lakatosh V.P., Lazarenko L.N., Lyanenko L.A., Dubchak V.E.: Present ideas on papillomavirus infection and its part in pathogenesis of pretumour and tumour processes in cervix uteri.Likars'ka Sprava (Kiev)2, 22–32 (1999).Google Scholar
  12. Meisels A., Ruiz P.:HPV and Cervical Cancer, pp. 67–85 (1989).Google Scholar
  13. Pinegin B.V., Minkina G.N., Korshunova O.V., Saprikin B.V., Saprikina O.A., Kulakov A.V., Bossart V., Karsonova M.I.: State of the local and system immunity in patients with papillomavirus cervical infection as affected by immunomodulator solkotrichovak.Immunologiya4, 45–48 (1997).Google Scholar
  14. Rast W.M., Feltkamp M.C.W., Ressing M.E.: Cellular immunity against human papillomavirus-associated cervical cancer.Semin. Virol.7, 117–123 (1986).Google Scholar
  15. Reid A., Stanhope C.R., Huschman B.R.: Colposcopia.Amer. J. Obstet. Gynecol.149, 815–823 (1984).Google Scholar
  16. Soutter W.P., Kesic V.: Treatment of cervical intraepithelial neoplasia reverses CD4CD8 lymphocyte abnormalities in peripheral venous-blood.Internat. J. Gynecol. Cancer4, 279–282 (1994).CrossRefGoogle Scholar
  17. Stern P.L.: Immunity to human papillomavirus-associated cervical neoplasia.Adv. Cancer Res.69, 175–211 (1996).PubMedGoogle Scholar
  18. Wu T.-C., Kurman R.J.: Analysis of cytokine profiles in patient with human papillomavirus associated neoplasms.J. Nat. Cancer Inst.89, 185–187 (1997).PubMedCrossRefGoogle Scholar

Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 1999

Authors and Affiliations

  • M. Ya. Spivak
    • 1
  • V. P. Lakatosh
    • 2
  • L. M. Lazarenko
    • 1
  • L. M. Lyanenko
    • 2
  • M. V. Azarskova
    • 1
  • O. M. Mikhailenko
    • 2
  • L'. Tkáčiková
    • 3
    • 4
  • A. M. Boroda
    • 2
  1. 1.Zabolotny Institute of Microbiology and VirologyNational Academy of Sciences of UkraineKievUkraine
  2. 2.Bogomolets National Medical UniversityKievUkraine
  3. 3.University of Veterinary MedicineKošiceSlovakia
  4. 4.Neuroimmunology InstituteSlovak Academy of SciencesBratislavaSlovakia

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