The Indian Journal of Pediatrics

, Volume 62, Issue 6, pp 695–701 | Cite as

Paradoxical response to antitubercular drugs

  • Sushil Kumar
  • Vinod Puri
  • M. M. Mehndiratta
  • Suvira Gupta
  • Ajay Bhutani
  • Chaitanya Sharma
Original Article


Seven patients with paradoxical response to antitubercular drugs are reported. In three cases of intracranial tuberculomas, newer lesions appeared and in two cases preexisting tuberculomas enlarged. In two cases of tubercular meningitis, multiple tuberculomas appeared. All these cases exhibited newer symptoms and CT/MBI revealed the paradoxical response to antituberculr drugs. All responded to continued conservative therapy, with addition of pyrazinamide.

Key words

Paradoxical response Pyrazinamide Blood brain Barrier Computed tomography Magnetic resonance imaging 


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Copyright information

© Dr. K C Chaudhuri Foundation 1995

Authors and Affiliations

  • Sushil Kumar
    • 1
  • Vinod Puri
    • 1
  • M. M. Mehndiratta
    • 1
  • Suvira Gupta
    • 1
  • Ajay Bhutani
    • 1
  • Chaitanya Sharma
    • 1
  1. 1.Department of Neurosurgery, Neurology and RadiologyG.B. Pant HospitalNew Delhi

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