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Paradoxical response to antitubercular drugs

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Abstract

Seven patients with paradoxical response to antitubercular drugs are reported. In three cases of intracranial tuberculomas, newer lesions appeared and in two cases preexisting tuberculomas enlarged. In two cases of tubercular meningitis, multiple tuberculomas appeared. All these cases exhibited newer symptoms and CT/MBI revealed the paradoxical response to antituberculr drugs. All responded to continued conservative therapy, with addition of pyrazinamide.

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Kumar, S., Puri, V., Mehndiratta, M.M. et al. Paradoxical response to antitubercular drugs. Indian J Pediatr 62, 695–701 (1995). https://doi.org/10.1007/BF02825120

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