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International Journal of Pancreatology

, Volume 21, Issue 2, pp 111–118 | Cite as

Evaluation of UICC TNM classification for pancreatic cancer

A study of 228 patients
  • Gianpaolo Balzano
  • Claudio Bassi
  • Alessandro Zerbi
  • Massimo Falconi
  • Giliola Calori
  • Giovanni Butturini
  • Biagio E. Leone
  • Paolo Pederzoli
  • Valerio Di Carlo
Original Articles

Summary

Conclusion

A different stage grouping of TNM factors can improve the predictivity of the UICC TNM classification for pancreatic cancer. Nevertheless, the Japanese Pancreas Society (JPS) classification maintains a higher prognostic value.

Background

The use of a reliable staging classification facilitates the evaluation of anticancer treatments and the correct management of patients. The aim of the present study was to evaluate the prognostic value of three modified UICC TNM classifications, obtained by different stage grouping of the UICC TNM factors, comparing their predictivity to the standard UICC and the JPS classifications.

Methods

Clinical material consisted of 228 patients who underwent resection for pancreatic cancer. The reliability of the classifications was analyzed by the following methods: univariate analysis of stage survival curves; multivariate analysis of each classification after adjusting for grading and radicality; and correlation between the patients' distribution in the stages of each classification and in survival classes.

Results

The following modfiied UICC classification allowed a better differentiation of stage II and III survival (P=0.08) than standard UICC (p=0.74): stage I: T1N0M0; stage II: T1N1M0/T2N0M0: stage III: T2N1M0/T3 any NM0; stage IV: M1. The JPS classification better discriminated between the different stages (P<0.001). All classifications had an independent prognostic value by multivariate analysis. The correlation between stages and survival classes was higher for the JPS classification than either UICC TNM classification or the modified UICC classifications.

Key Words

Pancreatic neoplasms neoplasm staging classification survival survival analysis surgery pathology 

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Copyright information

© Human Press Inc 1997

Authors and Affiliations

  • Gianpaolo Balzano
    • 2
  • Claudio Bassi
    • 1
  • Alessandro Zerbi
    • 2
  • Massimo Falconi
    • 1
  • Giliola Calori
    • 3
  • Giovanni Butturini
    • 1
  • Biagio E. Leone
    • 4
  • Paolo Pederzoli
    • 1
  • Valerio Di Carlo
    • 2
  1. 1.Department of SurgeryBorgoroma HospitalVeronaItaly
  2. 2.Department of SurgeryS. Raffaele HospitalMilanItaly
  3. 3.EpidemiologyS. Raffaele HospitalMilanItaly
  4. 4.PathologyS. Raffaele HospitalMilanItaly

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