Changes in blood chemistry, hematology, and histology caused by a selenium/vitamin E deficiency and recovery in chicks
- 206 Downloads
Exudative diathesis, a condition caused by a selenium (Se)/vitamin E deficiency, was studied in chicks. Trios of chicks that showed clinical signs of exudative diathesis were matched for severity. One was injected subcutaneously with 0.5 mL distilled water, and the other two received 15 μg of Se in 0.5 mL distilled water. A chick fed a diet with supplemental Se also received 0.5 mL distilled water. Blood was collected from three chicks 2 d after injection, and from the other chick, 6 d after injection. After blood was collected, pectoral muscle and bone marrow were collected. Deficient chicks showed varying degrees of necrosis in pectoral muscle, whereas recovring chicks had extensive fibrosis in pectoral muscle. An analysis of blood showed differences in CO2, glucose, Se, glutathione peroxidase, alanine aminotransferase, aspartate aminotransferase, and creatine kinase. Heterophils and monocytes were increased in deficient chicks; lymphocytes, basophils, and hemoglobin decreased. After 6 d of recovery, all of the changes noted above were correcting toward normal. Eosinophils, in contrast, were unaffected by a deficiency, but increased in recovering chicks. It is hypothesized that cytokines associated with the inflammatory response accentuate the clinical signs of exudative diathesis.
Index EntriesChicks selenium inflammatory response necrosis exudative diathesis
Unable to display preview. Download preview PDF.
- 3.E. L. R. Stokstad, E. L. Patterson, and R. Milstrey, Factors which prevent exudative diathesis in chicks on Torula yeast diets [Abstract],Poultry Sci. 36, 1160 (1957).Google Scholar
- 4.M. L. Scott, J. G. Bieri, G. M. Briggs, and K. Schwarz, Prevention of exudative diathesis by Factor 3 in chicks on vitamin E-deficient Torula yeast diets [Abstract],Poultry Sci. 36, 1155 (1957).Google Scholar
- 6.M. L. Scott, M. C. Nesheim, and R. J. Young,Nutrition of the Chicken, 3rd ed., M. L. Scott and Associates, Ithaca, pp. 350–353 (1982).Google Scholar
- 9.C. Riddell, Muscular system, inAvian Histopathology, American Association of Avian Pathologists, Kennett Square, PA, pp. 27–30 (1987).Google Scholar
- 10.C. Riddell, Cardiovascular system, inAvian Histopathology, American Association of Avian Pathologists, Kennett Square, PA, pp. 31–36 (1987).Google Scholar
- 11.R. E. Austic and M. L. Scott, Nutritional diseases, inDiseases of Poultry, 9th ed., B. W. Calnek, H. J. Barnes, C. W. Beard, W. M. Reid, and H. W. Yoder, Jr. eds., Iowa State University Press, Ames, IA, pp. 45–71 (1991).Google Scholar
- 12.J. Kuby,Immunology, 2nd ed., W.H. Freeman, New York, pp. 7–15,313–316 (1994).Google Scholar
- 13.L. R. McDowell, Selenium, inMinerals in Animal and Human Nutrition, Academic, New York, pp. 294–332 (1992).Google Scholar