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Chinese Journal of Clinical Oncology

, Volume 2, Issue 4, pp 737–743 | Cite as

Results of treating vertebral metastases by percutaneous vertebroplasty combined with interventional chemotherapy

  • Hongyi Cai
  • Xiaohu Wang
  • Huiping Cao
  • Xiaoqi Wang
  • Xiaodong Liu
  • Zhiyong Zhang
  • Xinchun Dong
Original Articles

Abstract

Objective

Vertebral metastases are a common manifestation in patients with advanced cancer and treatment is often ineffective. This study was conducted to explore the efficacy of treating vertebral metastases by percutaneous vertebroplasty (PVP) combined with interventional chemotherapy.

Methods

Seventy-five patients with vertebral metastases (42 men, 33 women; ages 31–76 years) were divided into 2 groups: 39 cases were treated by PVP combined with chemotherapy (VPCC group), and 36 cases were treated by PVP alone (VP group). All procedures were guided by computed tomography (CT) scanning. The results and complications were evaluated by a questionnaire regarding pain and routine follow-up.

Results

The response rate was significantly higher in the VPCC group than in the VP group (93.0% vs 74.4%, P<0.05); total response rates for the VPCC and VP groups were 25.6% and 10.3% respectively. A common complication related to VPCC was transient aggravating pain.

Conclusion

PVP may ameliorate pain, and consolidate the vertebrae of patients with vertebral metastases. Its short-term effect may be enhanced by adding drugs into the bone cement.

Keywords

vertebral metastases vertebroplasty radiology interventional tomography X-ray computed 

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Copyright information

© Chinese Anti-Cancer Association and Springer 2005

Authors and Affiliations

  • Hongyi Cai
    • 1
  • Xiaohu Wang
    • 1
  • Huiping Cao
    • 2
  • Xiaoqi Wang
    • 2
  • Xiaodong Liu
    • 2
  • Zhiyong Zhang
    • 2
  • Xinchun Dong
    • 3
  1. 1.Department of RadiotherapyGansu Provincial Tumor HospitalLanzhouChina
  2. 2.Department of RadiologyGansu Provincial Tumor HospitalLanzhouChina
  3. 3.Department of Tumor SurgeryGansu Provincial Tumor HospitalLanzhouChina

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