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Folia Microbiologica

, Volume 42, Issue 3, pp 193–198 | Cite as

Biological activity of new aza analogues of quinolones

  • A. Belicová
  • M. Seman
  • V. Milata
  • D. Ilavský
  • L. Ebringer
Papers

Abstract

A series of novel derivatives of 4H-pyrido[1,2-a]pyrimidine, 1,4-dihydro-4-oxo-1,5-naphthyridine and 1,4-dihydro-4-oxo-1,6-naphthyridine were prepared and their biological activity was compared with that of nalidixic acid. Thein vitro antibacterial activity of the tested compounds was lower than that of nalidixic acid except for two agents,1b and2c, with a higher activity againstEnterococcus faecalis. The compounds were tested for their ability to cure four plasmids from two species ofEnterobacteriaceae. The derivatives eliminated three plasmids (pKM101, pBR322, F'lac) at one-half or one-quarter of the minimal inhibitory concentration. Plasmid RP4 was unaffected by the treatment. None of these compounds showed better antichloroplast activity than nalidixic acid.

Keywords

Quinolones Nalidixic Acid Oxolinic Acid Cinoxacin Pipemidic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Folia Microbiologica 1997

Authors and Affiliations

  • A. Belicová
    • 1
  • M. Seman
    • 1
  • V. Milata
    • 2
  • D. Ilavský
    • 2
  • L. Ebringer
    • 1
  1. 1.Institute of Cellular BiologyComenius UniversityBratislavaSlovakia
  2. 2.Department of Organic ChemistrySlovak Technical UniversityBratislavaSlovakia

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