Abstract
Recombinagenic potential of the alkaloid cryptolepine was evaluated in two diploid strains ofAspergillus nidulans—a wild type strain (uvsH +//uvsH +) and a DNA-repair-deficient one (uvsH//uvsH). Treatment of both strains with cryptolepine failed to alter colony growth in culture; its recombinagenic potential was determined by the homozygotization index (in which events of mitotic exchange may cause expression of genes previously masked by the dominant allele). Mitotic crossing-overs were induced by 7 and 14 mg/L doses of cryptolepine in both diploidA. nidulans strains.
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Chiuchetta, S.J.R., Castro-Prado, M.A.A. Recombinagenic effect of cryptolepine inuvsH +//uvsH + anduvsH//uvsH diploid strains ofAspergillus nidulans . Folia Microbiol 47, 516–520 (2002). https://doi.org/10.1007/BF02818791
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DOI: https://doi.org/10.1007/BF02818791