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Folia Microbiologica

, Volume 47, Issue 3, pp 225–229 | Cite as

Copper complexes with bioactive ligands

Part II—Antifungal activity
  • B. Dudová
  • D. Hudecová
  • R. Pokorný
  • M. Mičková
  • M. Palicová
  • P. Segl'a
  • M. Melník
Papers

Abstract

Antifungal activity of new copper(II) complexes of 2-methylthionicotinate (2-MeSNic) of the composition Cu(2-MeSNic)2(MeNia)2·4H2O (where MeNia isN-methylnicotinamide), and Cu(2-MeSNic)2(Nia)2·2H2O (where Nia is nicotinamide) and Cu(2-MeSNic)2L2 (where L is isonicotinamide, iNia, or ethyl nicotinate, EtNic) were tested on various strains of filamentous fungi by the macrodilution method. Most sensitive against copper(II) adducts with bioactive ligands wereRhizopus oryzae andMicrosporum gypseum (IC50 1.5–2.3 mmol/L). The adducts with Nia, MeNia and EtNic at 5 mmol/L induced morphological changes in growing hyphae ofBotrytis cinerea, mainly their intensive branching attached to release of cytoplasm with partial growth inhibition. Inhibition of sporulation (>90%) ofAlternaria alternata by Cu(2-MeSNic)2·H2O was observed as a change in the color of the colonies. The highest resistance was marked byB. cinerea andFusarium moniliforme (average IC50 values 4.25 and 3.13 mmol/L, respectively). The presence of all bioactive ligands in copper(II) complexes caused an increase in the inhibition effect against model fungi (except significant inhibition activity of EtNic onR. oryzae).

Keywords

Antifungal Activity Filamentous Fungus Copper Complex Isonicotinamide Bioactive Ligand 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Folia Microbiologica 2002

Authors and Affiliations

  • B. Dudová
    • 1
  • D. Hudecová
    • 1
  • R. Pokorný
    • 1
  • M. Mičková
    • 1
  • M. Palicová
    • 2
  • P. Segl'a
    • 2
  • M. Melník
    • 2
  1. 1.Department of Biochemistry and Microbiology, Faculty of Chemical and Food TechnologySlovak University of TechnologyBratislavaSlovakia
  2. 2.Department of Inorganic Chemistry, Faculty of Chemical and Food TechnologySlovak University of TechnologyBratislavaSlovakia

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