Antimicrobial effects of the macrocyclic Cu(II)-tetraanhydroaminobenzaldehyde complex
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The Cu(II)-tetraaza macrocyclic complex exhibited antimicrobial effects on bacteria, yeasts and filamentous fungi. The highest antibacterial activity was found withB. subtilis andS. aureus, the respective IC50 values being 18 and 80 μg/L and the MIC values 50 and 1000 μg/L. A concentration of 1 mg/L exerted a bacteriocide effect onS. aureus. The MIC value forB. subtilis was 250 times lower and forP. aeruginosa 10 times lower than the corresponding values for ampicillin. The Cu-complex was inactive against all tested yeasts. The strongest antifungal effect was manifested forR. nigricans, with an IC50 value under 0.1 mg/L, whereas inA. alternata the IC50 was 13.5 mg/L.
KeywordsFilamentous Fungus Antimicrobial Effect Macrocyclic Ligand High Antibacterial Activity Candida Krusei
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