Abstract
The Cu(II)-tetraaza macrocyclic complex exhibited antimicrobial effects on bacteria, yeasts and filamentous fungi. The highest antibacterial activity was found withB. subtilis andS. aureus, the respective IC50 values being 18 and 80 μg/L and the MIC values 50 and 1000 μg/L. A concentration of 1 mg/L exerted a bacteriocide effect onS. aureus. The MIC value forB. subtilis was 250 times lower and forP. aeruginosa 10 times lower than the corresponding values for ampicillin. The Cu-complex was inactive against all tested yeasts. The strongest antifungal effect was manifested forR. nigricans, with an IC50 value under 0.1 mg/L, whereas inA. alternata the IC50 was 13.5 mg/L.
Similar content being viewed by others
References
Bencko V., Cikrt M., Lener J.:Toxic Metals in the Human Environment, pp. 177–184. (In Czech) GRADA Publishing, Prague 1995.
Ďuračková Z., Labuda J.: Superoxide dismutase mimetic activity of macrocyclic Cu(II)-tetraanhydroaminobenzaldehyde (TAAB) complex.J. Inorg. Biochem. 58, 297–303 (1995).
Ďuračková Z., Labudová O., Andrezáková L., Feníková L'., Labuda J., Kollárová M., Weser U.: Nuclease-like activity of a cyclic tetrameric Schiff base (tetraanhydroaminobenzaldehyde) N-coordinated copper complex.Int. J. Biochem. Cell Biol. 27, 1341–1346 (1995).
Hudecová D., Jantová S., Melník M., Uher M.: New azidometalkojates and their biological activity.Folia Microbiol. 41, 473–476 (1996).
Jantová S., Hudecová D., Stankovský, Š., Špirková K., Ružeková L'.: Antibacterial effect of substituted 4-quinazolylhydrazines and their arylhydrazones determined by a modified microdilution method.Folia Microbiol. 40, 611–614 (1995).
Melson C.A., Busch D.H.: The formation and properties of a tetradentate macrocyclic ligand by the self-condensation ofo-aminobenzaldehyde in the presence of metal ions.J. Am. Chem. Soc.,86, 4837 (1964).
Škárka B., Ferenčík M.:Biochemistry, p. 717. (In Slovak). ALFA, Bratislava 1992.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jantová, S., Labuda, J., Vollek, V. et al. Antimicrobial effects of the macrocyclic Cu(II)-tetraanhydroaminobenzaldehyde complex. Folia Microbiol 42, 324–326 (1997). https://doi.org/10.1007/BF02816943
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02816943