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Folia Microbiologica

, Volume 43, Issue 6, pp 683–686 | Cite as

Type I β-lactamases ofEnterobacter cloacae and resistance to β-lactam antibiotics

  • M. T. Tejedor-Junco
  • M. González-Martín
  • P. Lupiola
  • Z. González-Lama
Papers

Abstract

The interaction of type-I β-lactamases fromEnterobacter cloacae with diverse β-lactam compounds was examined. The ability of penicillin and cefoxitin to induce β-lactamase production in this strain was assessed. The effect of β-lactamase inhibitors was measured on β-lactamase extracts and on intact cells.E. cloacae 78 strain is a stably derepressed mutant showing limited susceptibility to a number of antibiotics except imipenem. Imipenem would therefore be the appropiate choice for therapy of infections caused by stably derepressed mutants ofEnterobacter sp. producing type-I β-lactamases.

Keywords

Imipenem Cefoxitin Clavulanic Acid Minimal Inhibitory Concentration Carbenicillin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 1998

Authors and Affiliations

  • M. T. Tejedor-Junco
    • 1
  • M. González-Martín
    • 1
  • P. Lupiola
    • 1
  • Z. González-Lama
    • 1
  1. 1.Departamento de Ciencias Clínicas, MicrobiologíaUniversidad de Las Palmas de Gran Canaria(Spain)

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