Abstract
The mutagenic activity of more than 120 antimicrobial agents and protective components was investigated. Only Kathon showed a consistent increase in revertant counts in the Ames test onSalmonella typhimurium. The hereditary bleaching test onEuglena gracilis used for detecting extranuclear mutations, showed positive results for Kathon, triethanolamine and diamine silver tetraborate.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Combes R.D., Haveland-Smith R.B.: A review of the genotoxicity of food, drug and cosmetic colours and other azo, triphenylmethane and xantene dyes.Mutat. Res. 98, 101–248 (1982).
Cramer M., Myers J.: Growth and photosynthetic characteristic ofEuglena gracilis.Arch. Mikrobiol. 17, 384–402 (1952).
Dušinská M., Slameňová D., Nadaska M.: Effect of silver compounds onin vitro cultured mammalian cells. I. Cytotoxic effect of diamine silver tetraborate on hamster cells.Biologia 45, 201–210 (1990).
Dušinská M., Slameňová D.: Effect of silver compounds onin vitro cultured mammalian cells. II. Study of genotoxicity and the effect of diamine silver tetraborate on macromolecule synthesis of V79 cells.Biologia 45, 211–218 (1990).
Ebringer L.: Die Erythromycinwirkung auf die FlagellatenEuglena gracilis Klebs.Naturwiss. 48, 606–607 (1961).
Ebringer L.: Interaction of drugs with extranuclear genetics elements and its consequences.Teratogen. Carcinogen. Mutagen. 10, 477–501 (1990).
Foltínová P., Grones J.: Protective effect of ascorbic acid on bleaching activity of N-methyl-N′-nitro-N-nitrosoguanidine and furazolidone.Folia Microbiol. 38, 501–504 (1993).
Chreňo O., Krajčovič J., Ebringer L., Polónyi J.: Effect of heat shock on the mutagenicity of mutagens and carcinogens inEuglena gracilis.Teratogen. Carcinogen. Mutagen. 8, 161–168 (1988).
IARC Monographs of the evaluation of carcinogenic risks to humans.International Agency for Research on Cancer, Vol. 57 (1993).
Mačor M., Ebringer L., Siekel P.: Hyperthermia and other factors increasing sensitivity ofEuglena to mutagens and carcinogens.Teratogen. Carcinogen. Mutagen. 5, 329–337 (1985).
Mačor M.: Streptomycin and N-methyl-N′-nitro-N-nitrosoguanidine inhibit incorporation of14C-precursors of macromolecule synthesis inEuglena gracilis.Folia Microbiol. 33, 466–473 (1988).
Mačor M., Ebringer L.: Effect of elevated temperature of genotoxicity of chemotherapeuticals towardEuglena gracilis.Folia Microbiol. 33, 314–322 (1988).
Maron D.M., Ames B.N.: Revised methods forSalmonella mutagenicity test.Mutat. Res. 113, 173–215 (1983).
McCalla D.R.: Effect of nitrofurans on the chloroplast system ofEuglena gracilis.J. Protozool.,12, 34–41 (1965).
McCalla D.R.: Mutation of theEuglena chloroplast system. The mechanism of bleaching by nitrosoguanidine and related compounds.J. Protozool. 14, 480–483 (1967).
McCalla D.R., Reuvers A.: Action of nitrofurane derivatives on the chloroplast system ofEuglena gracilis. Effect of light.J. Protozool. 17, 129–139 (1970).
Provasoli L., Hutner S.H., Schatz A.: Streptomycin-induced chlorophyll-less races ofEuglena.Proc. Soc. Exp. Biol. Med. 69, 279–282 (1948).
Sax N.Y., Lewis R.J.:Dangerous properties of industrial materials, 7th ed., p. 3370–3371. Van Norstrand Reinhold, New York 1989.
Wright C., Gingold E., Crofton-Sleigh C.: Mutagenic activity of Kathon an industrial biocide and cosmetic preservative containing 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one.Mutat. Res. 119, 35–43 (1983).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mačor, M., Beňo, J., Grones, J. et al. Euglena gracilis as a supplementary test organism for detecting biologically active compounds. Folia Microbiol 41, 48–52 (1996). https://doi.org/10.1007/BF02816340
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02816340